Zoniporide dihydrochloride | Tocris Bioscience 2727 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Zoniporide dihydrochloride

catalog :

2727

quantity :

10 mg (also 50 mg)

price :

224 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Feraille E, Dizin E, Roth I, Derouette J, Szanto I, Martin P, et al. NADPH oxidase 4 deficiency reduces aquaporin-2 mRNA expression in cultured renal collecting duct principal cells via increased PDE3 and PDE4 activity. PLoS ONE. 2014;9:e87239 pubmed publisher
Goldman A, Chen H, Khan M, Roesly H, Hill K, Shahidullah M, et al. The Na+/H+ exchanger controls deoxycholic acid-induced apoptosis by a H+-activated, Na+-dependent ionic shift in esophageal cells. PLoS ONE. 2011;6:e23835 pubmed publisher

product information

brand :

Tocris

master code :

2727

SKU :

2727/10

product name :

Zoniporide dihydrochloride

description :

Selective NHE1 inhibitor

target :

Na+ / H+ Exchanger Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

393.27

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor that displays selectivity over other NHE isoforms (Ki values are 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3 respectively). Inhibits NHE1 dependent 22Na+ uptake in vitro (IC50 = 14 nM) and provides cardioprotection from myocardial ischemic injury in vivo (EC50 = 0.25 nM). Also inhibits MMP2/9 activity and invasion in breast cancer cells.

catalog number base :

2727

extended description :

Selective NHE1 inhibitor

chemical name text :

[1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine dihydrochloride

formula :

C 17 H 16 N 6 O.2HCl

formula text :

C17H16N6O.2HCl

cas num :

241799-10-0

USD :

224 USD

alt names :

CP 597396

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage