SB 225002 | Tocris Bioscience 2725/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SB 225002

catalog :

2725/10

quantity :

10 mg (also 50 mg)

price :

287 USD

more info or order :

Tocris Bioscience product webpage

citations: 15

Reference
Chen J, Lai Y, Chu P, Chan S, Wang L, Hung W. Cancer-Derived VEGF-C Increases Chemokine Production in Lymphatic Endothelial Cells to Promote CXCR2-Dependent Cancer Invasion and MDSC Recruitment. Cancers (Basel). 2019;11: pubmed publisher
Brennan F, Jogia T, Gillespie E, Blomster L, Li X, Nowlan B, et al. Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2. JCI Insight. 2019;4: pubmed publisher
Karim H, Kim S, Lauderdale K, Lapato A, Atkinson K, Yasui N, et al. Analogues of ERβ ligand chloroindazole exert immunomodulatory and remyelinating effects in a mouse model of multiple sclerosis. Sci Rep. 2019;9:503 pubmed publisher
Saika F, Matsuzaki S, Kobayashi D, Kiguchi N, Kishioka S. Chemokine CXCL1 is responsible for cocaine-induced reward in mice. Neuropsychopharmacol Rep. 2018;38:145-148 pubmed publisher
Jung J, Kang K, Kim J, Hong S, Park Y, Kim B. CXCR2 Inhibition in Human Pluripotent Stem Cells Induces Predominant Differentiation to Mesoderm and Endoderm Through Repression of mTOR, ?-Catenin, and hTERT Activities. Stem Cells Dev. 2016;25:1006-19 pubmed publisher
Devapatla B, Sharma A, Woo S. CXCR2 Inhibition Combined with Sorafenib Improved Antitumor and Antiangiogenic Response in Preclinical Models of Ovarian Cancer. PLoS ONE. 2015;10:e0139237 pubmed publisher
Grabner B, Schramek D, Mueller K, Moll H, Svinka J, Hoffmann T, et al. Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis. Nat Commun. 2015;6:6285 pubmed publisher
Lourenço S, Teixeira V, Kalber T, José R, Floto R, Janes S. Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors. J Immunol. 2015;194:3463-74 pubmed publisher
Jung J, Lee S, Kim J, Lee S, Sung H, An J, et al. CXCR2 and its related ligands play a novel role in supporting the pluripotency and proliferation of human pluripotent stem cells. Stem Cells Dev. 2015;24:948-61 pubmed publisher
Raccosta L, Fontana R, Maggioni D, Lanterna C, Villablanca E, Paniccia A, et al. The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils. J Exp Med. 2013;210:1711-28 pubmed publisher
Raghuwanshi S, Smith N, Rivers E, Thomas A, Sutton N, Hu Y, et al. G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis. J Immunol. 2013;190:5329-36 pubmed publisher
Yuen D, Zhang Y, Thai K, Spring C, Chan L, Guo X, et al. Angiogenic dysfunction in bone marrow-derived early outgrowth cells from diabetic animals is attenuated by SIRT1 activation. Stem Cells Transl Med. 2012;1:921-6 pubmed publisher
Toh B, Wang X, Keeble J, Sim W, Khoo K, Wong W, et al. Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor. PLoS Biol. 2011;9:e1001162 pubmed publisher
Jang J, Hod E, Spitalnik S, Frenette P. CXCL1 and its receptor, CXCR2, mediate murine sickle cell vaso-occlusion during hemolytic transfusion reactions. J Clin Invest. 2011;121:1397-401 pubmed publisher
Lavoie Lamoureux A, Moran K, Beauchamp G, Mauel S, Steinbach F, Lefebvre Lavoie J, et al. IL-4 activates equine neutrophils and induces a mixed inflammatory cytokine expression profile with enhanced neutrophil chemotactic mediator release ex vivo. Am J Physiol Lung Cell Mol Physiol. 2010;299:L472-82 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2725

SKU :

2725/10

product name :

SB 225002

description :

Potent and selective CXCR2 antagonist

target :

Chemokine Receptor Antagonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at RT

observed molecular weight :

352.14

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SB 225002 is a potent and selective CXCR2 chemokine receptor antagonist (IC50 = 22 nM) that displays 150-fold selectivity over CXCR1 receptors. Causes inhibition of IL-8 and GRO -mediated calcium mobilization in HL60 cells (IC50 values are 8 and 10 nM respectively). Prevents IL-8-induced neutrophil chemotaxis in vitro and sequestration in vivo . Inhibits HIV replication in lymphocytes and macrophages.

product keywords :

Potent selective CXCR2 antagonists Chemokine Receptors SB225002 GlaxoSmithKline GSK Chemokine CXC Receptors 2725,

extended description :

Potent and selective CXCR2 antagonist

chemical name text :

N-(2-Bromophenyl)-N -(2-hydroxy-4-nitrophenyl)urea

formula :

C13H10BrN3O4

formula text :

C13H10BrN3O4

cas num :

182498-32-4

USD :

275

USD 2025 :

287 USD

product details :

Potent and selective CXCR2 antagonist

more info or order :

Tocris Bioscience product webpage