product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
SB 265610
catalog :
2724
quantity :
1 mg (also 10 mg, 50 mg)
price :
99 USD
more info or order :
citations: 8
Reference
He W, Holtkamp S, Hergenhan S, Kraus K, De Juan A, Weber J, et al. Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues. Immunity. 2018;49:1175-1190.e7 pubmed publisher
Jung J, Kang K, Kim J, Hong S, Park Y, Kim B. CXCR2 Inhibition in Human Pluripotent Stem Cells Induces Predominant Differentiation to Mesoderm and Endoderm Through Repression of mTOR, ?-Catenin, and hTERT Activities. Stem Cells Dev. 2016;25:1006-19 pubmed publisher
Esser von Bieren J, Volpe B, Sutherland D, Bürgi J, Verbeek J, Marsland B, et al. Immune antibodies and helminth products drive CXCR2-dependent macrophage-myofibroblast crosstalk to promote intestinal repair. PLoS Pathog. 2015;11:e1004778 pubmed publisher
Ha H, Bensman T, Ho H, Beringer P, Neamati N. A novel phenylcyclohex-1-enecarbothioamide derivative inhibits CXCL8-mediated chemotaxis through selective regulation of CXCR2-mediated signalling. Br J Pharmacol. 2014;171:1551-65 pubmed publisher
Toh B, Wang X, Keeble J, Sim W, Khoo K, Wong W, et al. Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor. PLoS Biol. 2011;9:e1001162 pubmed publisher
Halpern J, Kilbarger A, Lynch C. Mesenchymal stem cells promote mammary cancer cell migration in vitro via the CXCR2 receptor. Cancer Lett. 2011;308:91-9 pubmed publisher
Burton V, Ciuclan L, Holmes A, Rodman D, Walker C, Budd D. Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function. Blood. 2011;117:333-41 pubmed publisher
Lavoie Lamoureux A, Moran K, Beauchamp G, Mauel S, Steinbach F, Lefebvre Lavoie J, et al. IL-4 activates equine neutrophils and induces a mixed inflammatory cytokine expression profile with enhanced neutrophil chemotactic mediator release ex vivo. Am J Physiol Lung Cell Mol Physiol. 2010;299:L472-82 pubmed publisher
product information
brand :
Tocris
master code :
2724
SKU :
2724/1
product name :
SB 265610
description :
Potent CXCR2 antagonist
target :
Chemokine Receptor Antagonists
category :
Small Molecules
unit size :
1 mg (also 10 mg, 50 mg)
purity :
98%
observed molecular weight :
357.16
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca2+ mobilization (IC50 values are 3.4 and 6800 nM respectively). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo .
catalog number base :
2724
extended description :
Potent CXCR2 antagonist
chemical name text :
N-(2-Bromophenyl)-N -(7-cyano-1H-benzotriazol-4-yl)urea
formula :
C 14 H 9 BrN 6 O
formula text :
C14H9BrN6O
cas num :
211096-49-0
USD :
99 USD
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK