product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
SB 265610
catalog :
2724/1
quantity :
1 mg (also 10 mg, 50 mg)
price :
131 USD
more info or order :
citations: 11
Reference
He W, Holtkamp S, Hergenhan S, Kraus K, De Juan A, Weber J, et al. Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues. Immunity. 2018;49:1175-1190.e7 pubmed publisher
Taki M, Abiko K, Baba T, Hamanishi J, Yamaguchi K, Murakami R, et al. Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation. Nat Commun. 2018;9:1685 pubmed publisher
Jung J, Kang K, Kim J, Hong S, Park Y, Kim B. CXCR2 Inhibition in Human Pluripotent Stem Cells Induces Predominant Differentiation to Mesoderm and Endoderm Through Repression of mTOR, ?-Catenin, and hTERT Activities. Stem Cells Dev. 2016;25:1006-19 pubmed publisher
Esser von Bieren J, Volpe B, Sutherland D, Bürgi J, Verbeek J, Marsland B, et al. Immune antibodies and helminth products drive CXCR2-dependent macrophage-myofibroblast crosstalk to promote intestinal repair. PLoS Pathog. 2015;11:e1004778 pubmed publisher
Mishra H, Long C, Bahaie N, Walcheck B. Regulation of CXCR2 expression and function by a disintegrin and metalloprotease-17 (ADAM17). J Leukoc Biol. 2015;97:447-54 pubmed publisher
Jung J, Lee S, Kim J, Lee S, Sung H, An J, et al. CXCR2 and its related ligands play a novel role in supporting the pluripotency and proliferation of human pluripotent stem cells. Stem Cells Dev. 2015;24:948-61 pubmed publisher
Ha H, Bensman T, Ho H, Beringer P, Neamati N. A novel phenylcyclohex-1-enecarbothioamide derivative inhibits CXCL8-mediated chemotaxis through selective regulation of CXCR2-mediated signalling. Br J Pharmacol. 2014;171:1551-65 pubmed publisher
Toh B, Wang X, Keeble J, Sim W, Khoo K, Wong W, et al. Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor. PLoS Biol. 2011;9:e1001162 pubmed publisher
Halpern J, Kilbarger A, Lynch C. Mesenchymal stem cells promote mammary cancer cell migration in vitro via the CXCR2 receptor. Cancer Lett. 2011;308:91-9 pubmed publisher
Burton V, Ciuclan L, Holmes A, Rodman D, Walker C, Budd D. Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function. Blood. 2011;117:333-41 pubmed publisher
Lavoie Lamoureux A, Moran K, Beauchamp G, Mauel S, Steinbach F, Lefebvre Lavoie J, et al. IL-4 activates equine neutrophils and induces a mixed inflammatory cytokine expression profile with enhanced neutrophil chemotactic mediator release ex vivo. Am J Physiol Lung Cell Mol Physiol. 2010;299:L472-82 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2724
SKU :
2724/1
product name :
SB 265610
description :
Potent CXCR2 antagonist
target :
Chemokine Receptor Antagonists
unit size :
1 mg (also 10 mg, 50 mg)
category :
Small Molecules
purity :
98%
storage :
Store at RT
observed molecular weight :
357.16
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
SB 265610 is a potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca2+ mobilization (IC50 values are 3.4 and 6800 nM respectively). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo .
product keywords :
Potent CXCR2 antagonists Chemokine Receptors SB265610 GlaxoSmithKline GSK Chemokine CXC Receptors 2724,
extended description :
Potent CXCR2 antagonist
chemical name text :
N-(2-Bromophenyl)-N -(7-cyano-1H-benzotriazol-4-yl)urea
formula :
C14H9BrN6O
formula text :
C14H9BrN6O
cas num :
211096-49-0
USD :
129
USD 2025 :
131 USD
product details :
Potent CXCR2 antagonist
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK