LY 364947 | Tocris Bioscience 2718/1 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LY 364947

catalog :

2718/1

quantity :

1 mg (also 10 mg)

price :

125 USD

citations: 11

Reference
Al Ameri W, Ahmed I, Al Dasim F, Ali Mohamoud Y, Al Azwani I, Malek J, et al. Cell Type-Specific TGF-β Mediated EMT in 3D and 2D Models and Its Reversal by TGF-β Receptor Kinase Inhibitor in Ovarian Cancer Cell Lines. Int J Mol Sci. 2019;20: pubmed publisher
Yumoto K, Eber M, Wang J, Cackowski F, Decker A, Lee E, et al. Axl is required for TGF-Î²2-induced dormancy of prostate cancer cells in the bone marrow. Sci Rep. 2016;6:36520 pubmed publisher
Wang F, Wang X, Shapiro L, Cotrina M, Liu W, Wang E, et al. NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility. Brain Struct Funct. 2017;222:1543-1556 pubmed publisher
Oruqaj G, Karnati S, Vijayan V, Kotarkonda L, Boateng E, Zhang W, et al. Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-Î² signaling. Proc Natl Acad Sci U S A. 2015;112:E2048-57 pubmed publisher
Oshimori N, Oristian D, Fuchs E. TGF-β promotes heterogeneity and drug resistance in squamous cell carcinoma. Cell. 2015;160:963-976 pubmed publisher
Jajosky A, Coad J, Vos J, Martin K, Senft J, Wenger S, et al. RepSox slows decay of CD34+ acute myeloid leukemia cells and decreases T cell immunoglobulin mucin-3 expression. Stem Cells Transl Med. 2014;3:836-48 pubmed publisher
Sethi A, Wordinger R, Clark A. Gremlin utilizes canonical and non-canonical TGF? signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells. Exp Eye Res. 2013;113:117-27 pubmed publisher
Oerlecke I, Bauer E, Dittmer A, Leyh B, Dittmer J. Cyclic AMP enhances TGF? responses of breast cancer cells by upregulating TGF? receptor I expression. PLoS ONE. 2013;8:e54261 pubmed publisher
Hough C, Radu M, Doré J. Tgf-beta induced Erk phosphorylation of smad linker region regulates smad signaling. PLoS ONE. 2012;7:e42513 pubmed publisher
Sethi A, Jain A, Zode G, Wordinger R, Clark A. Role of TGFbeta/Smad signaling in gremlin induction of human trabecular meshwork extracellular matrix proteins. Invest Ophthalmol Vis Sci. 2011;52:5251-9 pubmed publisher
Sethi A, Mao W, Wordinger R, Clark A. Transforming growth factor-beta induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2011;52:5240-50 pubmed publisher

product information

brand :

Tocris

master code :

2718

SKU :

2718/1

rank :

0.061

product name :

LY 364947

description :

Selective inhibitor of TGF- RI

target :

TGF-beta Receptor Inhibitors

category :

Small Molecules

sizes available :

1 mg (also 10 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

LY 364947 is a selective inhibitor of TGF- type-I receptor (TGF- RI, TGFR-I, T R-I, ALK-5) (IC50 values are 59, 400 and 1400 nM for TGR- RI, TGF- RII and MLK-7K respectively). Inhibits TGF- -dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC50 values are 47 and 89 nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay.

extended description :

Selective inhibitor of TGF- RI

chemical name text :

4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-quinoline

formula :

C 17 H 12 N 4

formula text :

C17H12N4

cas num :

396129-53-6

USD :

125 USD

product details :

Selective inhibitor of TGF- RI

alt names :

HTS 466284

storage :

Store the unopened product at room temperature. Do not use past expiration date.