BIBP 3226 trifluoroacetate | Tocris Bioscience 2707/1 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BIBP 3226 trifluoroacetate

catalog :

2707/1

quantity :

1 mg (also 10 mg)

price :

151 USD

citations: 14

Reference
Acton D, Ren X, Di Costanzo S, Dalet A, Bourane S, Bertocchi I, et al. Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch. Cell Rep. 2019;28:625-639.e6 pubmed publisher
Businaro R, Scaccia E, Bordin A, Pagano F, Corsi M, Siciliano C, et al. Platelet Lysate-Derived Neuropeptide y Influences Migration and Angiogenesis of Human Adipose Tissue-Derived Stromal Cells. Sci Rep. 2018;8:14365 pubmed publisher
Raza S, Albrecht A, Caliskan G, Muller B, Demiray Y, Ludewig S, et al. HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience. Nat Commun. 2017;8:189 pubmed publisher
Martins J, Elvas F, Brudzewsky D, Martins T, Kolomiets B, TralhÃ£o P, et al. Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro. ASN Neuro. 2015;7: pubmed publisher
Aveleira C, Botelho M, Carmo Silva S, Pascoal J, Ferreira Marques M, NÃ³brega C, et al. Neuropeptide Y stimulates autophagy in hypothalamic neurons. Proc Natl Acad Sci U S A. 2015;112:E1642-51 pubmed publisher
Pleil K, Rinker J, Lowery Gionta E, Mazzone C, McCall N, Kendra A, et al. NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nat Neurosci. 2015;18:545-52 pubmed publisher
Zacharia J, Mauban J, Raina H, Fisher S, WIER W. High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via ?1A- and ?1D-adrenoceptor subtypes. PLoS ONE. 2013;8:e65969 pubmed publisher
Santos Carvalho A, Elvas F, Alvaro A, Ambrósio A, Cavadas C. Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate. Cell Death Dis. 2013;4:e636 pubmed publisher
REIDELBERGER R, Haver A, Chelikani P. Role of peptide YY(3-36) in the satiety produced by gastric delivery of macronutrients in rats. Am J Physiol Endocrinol Metab. 2013;304:E944-50 pubmed publisher
Novielli N, Al Khazraji B, Medeiros P, Goldman D, Jackson D. Pre-diabetes augments neuropeptide Y1- and ?1-receptor control of basal hindlimb vascular tone in young ZDF rats. PLoS ONE. 2012;7:e46659 pubmed publisher
Sparrow A, Lowery Gionta E, Pleil K, Li C, Sprow G, Cox B, et al. Central neuropeptide Y modulates binge-like ethanol drinking in C57BL/6J mice via Y1 and Y2 receptors. Neuropsychopharmacology. 2012;37:1409-21 pubmed publisher
Yi C, Foppen E, Abplanalp W, Gao Y, Alkemade A, la Fleur S, et al. Glucocorticoid signaling in the arcuate nucleus modulates hepatic insulin sensitivity. Diabetes. 2012;61:339-45 pubmed publisher
Pleil K, Lopez A, McCall N, Jijon A, Bravo J, Kash T. Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice. Neuropharmacology. 2012;62:1777-86 pubmed publisher
Son M, Kim M, Yu K, Koo D, Cho Y. Involvement of neuropeptide Y and its Y1 and Y5 receptors in maintaining self-renewal and proliferation of human embryonic stem cells. J Cell Mol Med. 2011;15:152-65 pubmed publisher

product information

brand :

Tocris

MasterCode :

2707

SKU :

2707/1

product name :

BIBP 3226 trifluoroacetate

unit sizes :

1 mg (also 10 mg)

description :

Mixed NPY Y1 and NPFF receptor antagonist

target :

NPY Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

473.57

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BIBP 3226 trifluoroacetate is a mixed non-peptide neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist (Ki values are 1.1, 79, 108, 1000, 1000 and 1000 for rNPY Y1, hNPFF2, rNPFF, rNPY Y2, rNPY Y4 and rNPY Y5 respectively). Produces an anxiogenic-like effect in rats following i.c.v. administration.

extended description :

Mixed NPY Y1 and NPFF receptor antagonist

chemical name text :

N-[(1R)]-4-[(Aminoiminomethyl)amino-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl- -phenylbenzeneacetamide

formula :

C 27 H 31 N 5 O 3

formula text :

C27H31N5O3

cas num :

159013-54-4

USD :

151 USD

product details :

Mixed NPY Y1 and NPFF receptor antagonist

storage :

Store at -20°C