Temozolomide | Tocris Bioscience 2706 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Temozolomide

catalog :

2706

quantity :

10 mg (also 50 mg)

price :

91 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Deng L, Ng L, Ozawa T, Stella N. Quantitative Analyses of Synergistic Responses between Cannabidiol and DNA-Damaging Agents on the Proliferation and Viability of Glioblastoma and Neural Progenitor Cells in Culture. J Pharmacol Exp Ther. 2017;360:215-224 pubmed publisher
Canello T, Ovadia H, Refael M, Zrihan D, Siegal T, Lavon I. Antineoplastic effect of decoy oligonucleotide derived from MGMT enhancer. PLoS ONE. 2014;9:e113854 pubmed publisher
Pastori C, Daniel M, Penas C, Volmar C, Johnstone A, Brothers S, et al. BET bromodomain proteins are required for glioblastoma cell proliferation. Epigenetics. 2014;9:611-20 pubmed publisher
Prabhu A, Sarcar B, Kahali S, Shan Y, Chinnaiyan P. Targeting the unfolded protein response in glioblastoma cells with the fusion protein EGF-SubA. PLoS ONE. 2012;7:e52265 pubmed publisher
Johannessen T, Prestegarden L, Grudic A, Hegi M, Tysnes B, Bjerkvig R. The DNA repair protein ALKBH2 mediates temozolomide resistance in human glioblastoma cells. Neuro Oncol. 2013;15:269-78 pubmed publisher
Hu B, Nandhu M, Sim H, Agudelo Garcia P, Saldivar J, Dolan C, et al. Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling. Cancer Res. 2012;72:3873-85 pubmed publisher

product information

brand :

Tocris

master code :

2706

SKU :

2706/10

product name :

Temozolomide

description :

DNA-methylating antitumor agent

target :

Apoptosis Inducer Compounds

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

194.15

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

DNA methylating, chemotherapeutic agent. Displays antitumor activity against a board spectrum of tumors, including leukemias, lymphomas and solid tumors (IC50 = 5.0 u M for cytotoxicity against mouse TLX5 lymphoma cells). Induces autophagy in malignant glioma cells. Exhibits enhanced activity when used in combination with CHC (Cat No. 5029).

catalog number base :

2706

extended description :

DNA-methylating antitumor agent

chemical name text :

3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide

formula :

C 6 H 6 N 6 O 2

formula text :

C6H6N6O2

cas num :

85622-93-1

USD :

91 USD

alt names :

NSC 362856, CCRG 81045

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage