Temozolomide | Tocris Bioscience 2706/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Temozolomide

catalog :

2706/10

quantity :

10 mg (also 50 mg)

price :

127 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Deng L, Ng L, Ozawa T, Stella N. Quantitative Analyses of Synergistic Responses between Cannabidiol and DNA-Damaging Agents on the Proliferation and Viability of Glioblastoma and Neural Progenitor Cells in Culture. J Pharmacol Exp Ther. 2017;360:215-224 pubmed publisher
Svalina M, Kikuchi K, Abraham J, Lal S, Davare M, Settelmeyer T, et al. IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma. Sci Rep. 2016;6:27012 pubmed publisher
Canello T, Ovadia H, Refael M, Zrihan D, Siegal T, Lavon I. Antineoplastic effect of decoy oligonucleotide derived from MGMT enhancer. PLoS ONE. 2014;9:e113854 pubmed publisher
Pastori C, Daniel M, Penas C, Volmar C, Johnstone A, Brothers S, et al. BET bromodomain proteins are required for glioblastoma cell proliferation. Epigenetics. 2014;9:611-20 pubmed publisher
Prabhu A, Sarcar B, Kahali S, Shan Y, Chinnaiyan P. Targeting the unfolded protein response in glioblastoma cells with the fusion protein EGF-SubA. PLoS ONE. 2012;7:e52265 pubmed publisher
Johannessen T, Prestegarden L, Grudic A, Hegi M, Tysnes B, Bjerkvig R. The DNA repair protein ALKBH2 mediates temozolomide resistance in human glioblastoma cells. Neuro Oncol. 2013;15:269-78 pubmed publisher
Hu B, Nandhu M, Sim H, Agudelo Garcia P, Saldivar J, Dolan C, et al. Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling. Cancer Res. 2012;72:3873-85 pubmed publisher
Cheng Y, Sk U, Zhang Y, Ren X, Zhang L, Huber Keener K, et al. Rational incorporation of selenium into temozolomide elicits superior antitumor activity associated with both apoptotic and autophagic cell death. PLoS ONE. 2012;7:e35104 pubmed publisher
Dittmann L, Danner A, Gronych J, Wolter M, Stuhler K, Grzendowski M, et al. Downregulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumours and increases radio- and chemosensitivity of Hs683 glioma cells in vitro. Oncogene. 2012;31:3409-18 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2706

SKU :

2706/10

product name :

Temozolomide

description :

DNA-methylating antitumor agent

target :

Apoptosis Inducer Compounds

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at RT

observed molecular weight :

194.15

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Temozolomide is a DNA methylating, chemotherapeutic agent. Displays antitumor activity against a board spectrum of tumors, including leukemias, lymphomas and solid tumors (IC50 = 5.0 u M for cytotoxicity against mouse TLX5 lymphoma cells). Induces autophagy in malignant glioma cells. Exhibits enhanced activity when used in combination with CHC (Cat No. 5029).

product keywords :

DNA-methylating antitumor agent Apoptosis Inducer NSC362856 CCRG81045 chemotherapeutics TMZ NSC 362856 CCRG 81045 Apoptosis Inducers Autophagy 2706,

extended description :

DNA-methylating antitumor agent

chemical name text :

3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide

formula :

C6H6N6O2

formula text :

C6H6N6O2

cas num :

85622-93-1

USD :

121

USD 2025 :

127 USD

product details :

DNA-methylating antitumor agent

alt names :

NSC 362856,CCRG 81045

more info or order :

Tocris Bioscience product webpage