Calcipotriol | Tocris Bioscience 2700/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Calcipotriol

catalog :

2700/10

quantity :

10 mg (also 50 mg)

price :

280 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Mishra S, Wheeler J, Pitake S, Ding H, Jiang C, Fukuyama T, et al. Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch. Cell Rep. 2020;31:107472 pubmed publisher
Wei Z, Yoshihara E, He N, Hah N, Fan W, Pinto A, et al. Vitamin D Switches BAF Complexes to Protect β Cells. Cell. 2018;173:1135-1149.e15 pubmed publisher
Malhotra N, Leyva Castillo J, Jadhav U, Barreiro O, Kam C, O Neill N, et al. RORα-expressing T regulatory cells restrain allergic skin inflammation. Sci Immunol. 2018;3: pubmed publisher
Landheer J, Giovannone B, Sadekova S, Tjabringa S, Hofstra C, Dechering K, et al. TSLP is differentially regulated by vitamin D3 and cytokines in human skin. Immun Inflamm Dis. 2015;3:32-43 pubmed publisher

product information

brand :

Tocris

catalog number base :

2700

SKU :

2700/10

product name :

Calcipotriol

units size :

10 mg (also 50 mg)

description :

Vitamin D3 analog

target :

Additional VDR-like Receptor Compounds

category :

Small Molecules

purity :

98%

observed molecular weight :

412.6

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

review stars :

details of functionality :

Calcipotriol is a vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60/MX2, keratinocytes, MCF-7, T47D, SCC-25, and mouse WEHI-3 cancer cell lines. Calcipotriol suppresses skin cancer development in mice in a thymic stromal lymphopoietin (TSLP)-dependent manner. Calcipotriol promotes the differentiation of keratinocytes. In human T cells and in psoriatic skin, Calcipotriol increases IL-10 secretion, induces secretion of type 2 cytokines by T cells and modulates the differentiation of dendritic cells and T cells.

top caption :

Vitamin D3 analog

extended description :

Vitamin D3 analog

chemical name text :

(1 ,3 ,5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol

formula :

C27H40O3

formula text :

C27H40O3

cas num :

112965-21-6

USD :

280 USD

product details :

Vitamin D3 analog

alt names :

MC 903

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage