PD 407824 | Tocris Bioscience 2694/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PD 407824

catalog :

2694/1

quantity :

1 mg (also 10 mg)

price :

132 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Liu S, Liu Y, Minami K, Chen A, Wan Q, Yin Y, et al. Inhibiting checkpoint kinase 1 protects bone from bone resorption by mammary tumor in a mouse model. Oncotarget. 2018;9:9364-9378 pubmed publisher
Kishikawa T, Otsuka M, Tan P, Ohno M, Sun X, Yoshikawa T, et al. Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine. Oncotarget. 2015;6:8339-52 pubmed
Pouliot L, Chen Y, Bai J, Guha R, Martin S, Gottesman M, et al. Cisplatin sensitivity mediated by WEE1 and CHK1 is mediated by miR-155 and the miR-15 family. Cancer Res. 2012;72:5945-55 pubmed publisher
Azorsa D, Gonzales I, Basu G, Choudhary A, Arora S, Bisanz K, et al. Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. J Transl Med. 2009;7:43 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2694

SKU :

2694/1

product name :

PD 407824

description :

Potent and selective inhibitor of Chk1 and Wee1

target :

Checkpoint Kinase Inhibitors

unit size :

1 mg (also 10 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

328.32

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PD 407824 is a potent and selective inhibitor of checkpoint kinases Chk1 and Wee1 (IC50 values are 47 and 97 nM respectively). Displays selectivity over a range of other protein kinases; IC50 values are 3.4, 3.75, 5, 50, 50 and 50 u M for PKC, CDK4, other CDKs, c-Src, PDGFR and FGFR respectively. Also sensitizes hESCs to BMP4 to induce differentiation.

product keywords :

Selective inhibitors inhibits Chk1 Wee1 Checkpoint Control Kinases PD407824 Pfizer BMP4 sensitizes sensitizers Checkpoint Kinases Checkpoint Control Kinases BMP and Other Activin Receptors ESCs and iPSC 2694,

extended description :

Potent and selective inhibitor of Chk1 and Wee1

chemical name text :

9-Hydroxy-4-phenyl-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione

formula :

C20H12N2O3

formula text :

C20H12N2O3

cas num :

622864-54-4

USD :

146

USD 2025 :

132 USD

product details :

Potent and selective inhibitor of Chk1 and Wee1

more info or order :

Tocris Bioscience product webpage