POM 1 | Tocris Bioscience 2689 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

POM 1

catalog :

2689

quantity :

50 mg

price :

103 USD

more info or order :

Tocris Bioscience product webpage

citations: 12

Reference
Burr A, Parekkadan B. Kinetics of MSC-based enzyme therapy for immunoregulation. J Transl Med. 2019;17:263 pubmed publisher
Alvarez Sánchez N, Cruz Chamorro I, Díaz Sánchez M, Lardone P, Guerrero J, Carrillo Vico A. Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients. Sci Rep. 2019;9:2302 pubmed publisher
Ohradanova Repic A, Machacek C, Charvet C, Lager F, Le Roux D, Platzer R, et al. Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances. Front Immunol. 2018;9:852 pubmed publisher
Crittenden S, Cheyne A, Adams A, Forster T, Robb C, Felton J, et al. Purine metabolism controls innate lymphoid cell function and protects against intestinal injury. Immunol Cell Biol. 2018;96:1049-1059 pubmed publisher
Hirata Y, Furuhashi K, Ishii H, Li H, Pinho S, Ding L, et al. CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine. Cell Stem Cell. 2018;22:445-453.e5 pubmed publisher
Del Papa B, Pierini A, Sportoletti P, Baldoni S, Cecchini D, Rosati E, et al. The NOTCH1/CD39 axis: a Treg trip-switch for GvHD. Leukemia. 2016;30:1931-4 pubmed publisher
Aho J, Helenius M, Vattulainen Collanus S, Alastalo T, Koskenvuo J. Extracellular ATP protects endothelial cells against DNA damage. Purinergic Signal. 2016;12:575-81 pubmed publisher
Fang F, Yu M, Cavanagh M, Hutter Saunders J, Qi Q, Ye Z, et al. Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals. Cell Rep. 2016;14:1218-1231 pubmed publisher
Sassi Y, Ahles A, Truong D, Baqi Y, Lee S, Husse B, et al. Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation. J Clin Invest. 2014;124:5385-97 pubmed publisher
Rao S, Tortola L, Perlot T, Wirnsberger G, Novatchkova M, Nitsch R, et al. A dual role for autophagy in a murine model of lung cancer. Nat Commun. 2014;5:3056 pubmed publisher
Pinheiro A, Paramos de Carvalho D, Certal M, Costa C, Magalhães Cardoso M, Ferreirinha F, et al. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal. 2013;11:70 pubmed publisher
Yegutkin G, Wieringa B, Robson S, Jalkanen S. Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities. FASEB J. 2012;26:3875-83 pubmed publisher

product information

brand :

Tocris

master code :

2689

SKU :

2689/50

product name :

POM 1

description :

Inhibitor of E-NTPDases

target :

NTPDase Inhibitors

category :

Small Molecules

unit size :

50 mg

observed molecular weight :

2986.01

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of Ecto-NTPDases that displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 and P2Y12 (Ki values are 2.58, 3.26, 10 and 28.8 u M for NTPDase 1, NTPDase 3, P2Y12 and NTPDase 2 respectively). Abolishes renal protection induced by ischemic preconditioning. Inhibits synaptic transmission at hippocampal CA1 pyramidal synapses and at the cerebellar parallel fiber-Purkinje cell (PF) synapse.

catalog number base :

2689

extended description :

Inhibitor of E-NTPDases

chemical name text :

Sodium metatungstate

formula :

H 2 O 40 Na 6 W 12

formula text :

H2O40Na6W12

cas num :

12141-67-2

USD :

103 USD

alt names :

Sodium polyoxotungstate

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage