POM 1 | Tocris Bioscience 2689/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

POM 1

catalog :

2689/50

quantity :

50 mg

price :

143 USD

more info or order :

Tocris Bioscience product webpage

citations: 16

Reference
Burr A, Parekkadan B. Kinetics of MSC-based enzyme therapy for immunoregulation. J Transl Med. 2019;17:263 pubmed publisher
Alvarez Sánchez N, Cruz Chamorro I, Díaz Sánchez M, Lardone P, Guerrero J, Carrillo Vico A. Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients. Sci Rep. 2019;9:2302 pubmed publisher
Ohradanova Repic A, Machacek C, Charvet C, Lager F, Le Roux D, Platzer R, et al. Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances. Front Immunol. 2018;9:852 pubmed publisher
Crittenden S, Cheyne A, Adams A, Forster T, Robb C, Felton J, et al. Purine metabolism controls innate lymphoid cell function and protects against intestinal injury. Immunol Cell Biol. 2018;96:1049-1059 pubmed publisher
Hirata Y, Furuhashi K, Ishii H, Li H, Pinho S, Ding L, et al. CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine. Cell Stem Cell. 2018;22:445-453.e5 pubmed publisher
Chiu D, Tse A, Xu I, Di Cui J, Lai R, Li L, et al. Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma. Nat Commun. 2017;8:517 pubmed publisher
Del Papa B, Pierini A, Sportoletti P, Baldoni S, Cecchini D, Rosati E, et al. The NOTCH1/CD39 axis: a Treg trip-switch for GvHD. Leukemia. 2016;30:1931-4 pubmed publisher
Aho J, Helenius M, Vattulainen Collanus S, Alastalo T, Koskenvuo J. Extracellular ATP protects endothelial cells against DNA damage. Purinergic Signal. 2016;12:575-81 pubmed publisher
Fang F, Yu M, Cavanagh M, Hutter Saunders J, Qi Q, Ye Z, et al. Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals. Cell Rep. 2016;14:1218-1231 pubmed publisher
Sassi Y, Ahles A, Truong D, Baqi Y, Lee S, Husse B, et al. Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation. J Clin Invest. 2014;124:5385-97 pubmed publisher
Purvis H, Anderson A, Young D, Isaacs J, Hilkens C. A negative feedback loop mediated by STAT3 limits human Th17 responses. J Immunol. 2014;193:1142-50 pubmed publisher
Rao S, Tortola L, Perlot T, Wirnsberger G, Novatchkova M, Nitsch R, et al. A dual role for autophagy in a murine model of lung cancer. Nat Commun. 2014;5:3056 pubmed publisher
Pinheiro A, Paramos de Carvalho D, Certal M, Costa C, Magalhães Cardoso M, Ferreirinha F, et al. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal. 2013;11:70 pubmed publisher
Chen M, Su W, Lin X, Guo Z, Wang J, Zhang Q, et al. Adoptive transfer of human gingiva-derived mesenchymal stem cells ameliorates collagen-induced arthritis via suppression of Th1 and Th17 cells and enhancement of regulatory T cell differentiation. Arthritis Rheum. 2013;65:1181-93 pubmed publisher
Visovatti S, Hyman M, Bouïs D, Neubig R, McLaughlin V, Pinsky D. Increased CD39 nucleotidase activity on microparticles from patients with idiopathic pulmonary arterial hypertension. PLoS ONE. 2012;7:e40829 pubmed publisher
Yegutkin G, Wieringa B, Robson S, Jalkanen S. Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities. FASEB J. 2012;26:3875-83 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2689

SKU :

2689/50

product name :

POM 1

description :

Inhibitor of E-NTPDases

target :

NTPDase Inhibitors

unit size :

50 mg

category :

Small Molecules

storage :

Store at RT

observed molecular weight :

2986.01

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

POM 1 is an inhibitor of Ecto-NTPDases that displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 and P2Y12 (Ki values are 2.58, 3.26, 10 and 28.8 u M for NTPDase 1, NTPDase 3, P2Y12 and NTPDase 2 respectively). Abolishes renal protection induced by ischemic preconditioning. Inhibits synaptic transmission at hippocampal CA1 pyramidal synapses and at the cerebellar parallel fiber-Purkinje cell (PF) synapse.

product keywords :

inhibitors inhibits E-NTPDases ATPases POM1 Sodium polyoxotungstate NTPDase 2689,

extended description :

Inhibitor of E-NTPDases

chemical name text :

Sodium metatungstate

formula :

H2O40Na6W12

formula text :

H2O40Na6W12

cas num :

12141-67-2

USD :

137

USD 2025 :

143 USD

product details :

Inhibitor of E-NTPDases

alt names :

Sodium polyoxotungstate

more info or order :

Tocris Bioscience product webpage