SN 38 | Tocris Bioscience 2684/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SN 38

catalog :

2684/10

quantity :

10 mg (also 50 mg)

price :

161 USD

more info or order :

Tocris Bioscience product webpage

citations: 10

Reference
Prill S, Rebstock J, Tennemann A, Körfer J, Sönnichsen R, Thieme R, et al. Tumor-associated macrophages and individual chemo-susceptibility are influenced by iron chelation in human slice cultures of gastric cancer. Oncotarget. 2019;10:4731-4742 pubmed publisher
Guillon J, Petit C, Moreau M, Toutain B, Henry C, Roche H, et al. Regulation of senescence escape by TSP1 and CD47 following chemotherapy treatment. Cell Death Dis. 2019;10:199 pubmed publisher
Wolff D, Lee M, Jothi M, Mal M, Li F, Mal A. Camptothecin exhibits topoisomerase1-independent KMT1A suppression and myogenic differentiation in alveolar rhabdomyosarcoma cells. Oncotarget. 2018;9:25796-25807 pubmed publisher
Le Duff M, Gouju J, Jonchère B, Guillon J, Toutain B, Boissard A, et al. Regulation of senescence escape by the cdk4-EZH2-AP2M1 pathway in response to chemotherapy. Cell Death Dis. 2018;9:199 pubmed publisher
VÃ©tillard A, JonchÃ¨re B, Moreau M, Toutain B, Henry C, Fontanel S, et al. Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis. Oncotarget. 2015;6:43342-62 pubmed publisher
JonchÃ¨re B, VÃ©tillard A, Toutain B, Lam D, Bernard A, Henry C, et al. Irinotecan treatment and senescence failure promote the emergence of more transformed and invasive cells that depend on anti-apoptotic Mcl-1. Oncotarget. 2015;6:409-26 pubmed
Chen J, Shepherd M, Horn J, Leggas M, Rohr J. Enzymatic methylation and structure-activity-relationship studies on polycarcin V, a gilvocarcin-type antitumor agent. Chembiochem. 2014;15:2729-35 pubmed publisher
Kathawala R, Chen J, Zhang Y, Wang Y, Patel A, Wang D, et al. Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance. Int J Oncol. 2014;44:1634-42 pubmed publisher
Ni Z, Bikadi Z, Shuster D, Zhao C, Rosenberg M, Mao Q. Identification of proline residues in or near the transmembrane helices of the human breast cancer resistance protein (BCRP/ABCG2) that are important for transport activity and substrate specificity. Biochemistry. 2011;50:8057-66 pubmed publisher
Ni Z, Bikadi Z, Cai X, Rosenberg M, Mao Q. Transmembrane helices 1 and 6 of the human breast cancer resistance protein (BCRP/ABCG2): identification of polar residues important for drug transport. Am J Physiol Cell Physiol. 2010;299:C1100-9 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2684

SKU :

2684/10

product name :

SN 38

description :

DNA topoisomerase I inhibitor; antitumor

target :

DNA Topoisomerase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

392.4

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SN 38 is an active metabolite of CPT-11 (Cat. No. 2688) that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 u M in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1.3 u M respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).

product keywords :

DNA topoisomerase I inhibitors inhibits antitumor Isomerases SN38 chemotherapeutics 7-Ethyl-10-hydroxycamptothecin DNA Topoisomerase 2684,

extended description :

DNA topoisomerase I inhibitor; antitumor

chemical name text :

(4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3 ,4 :6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione

formula :

C22H20N2O5

formula text :

C22H20N2O5

cas num :

86639-52-3

USD :

156

USD 2025 :

161 USD

product details :

DNA topoisomerase I inhibitor; antitumor

alt names :

7-Ethyl-10-hydroxycamptothecin

more info or order :

Tocris Bioscience product webpage