Sodium 4-Phenylbutyrate | Tocris Bioscience 2682/100 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Sodium 4-Phenylbutyrate

catalog :

2682/100

quantity :

100 mg

price :

135 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Myszor I, Parveen Z, Ottosson H, Bergman P, Agerberth B, Stromberg R, et al. Novel aroylated phenylenediamine compounds enhance antimicrobial defense and maintain airway epithelial barrier integrity. Sci Rep. 2019;9:7114 pubmed publisher
Seshadri C, Sedaghat N, Campo M, Peterson G, Wells R, Olson G, et al. Transcriptional networks are associated with resistance to Mycobacterium tuberculosis infection. PLoS ONE. 2017;12:e0175844 pubmed publisher
Karadottir H, Kulkarni N, Gudjonsson T, Karason S, Gudmundsson G. Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cells. Peerj. 2015;3:e1483 pubmed publisher
Kulkarni N, Yi Z, Huehnken C, Agerberth B, Gudmundsson G. Phenylbutyrate induces cathelicidin expression via the vitamin D receptor: Linkage to inflammatory and growth factor cytokines pathways. Mol Immunol. 2015;63:530-9 pubmed
Khan Z, Akhtar M, Ekström T. HDAC inhibitor 4-phenylbutyrate preserves immature phenotype of human embryonic midbrain stem cells: implications for the involvement of DNA methyltransferase. Int J Mol Med. 2011;28:977-83 pubmed publisher

product information

brand :

Tocris

catalog number base :

2682

SKU :

2682/100

product name :

Sodium 4-Phenylbutyrate

units size :

100 mg

description :

Histone deacetylase inhibitor

target :

Class I Histone Deacetylases Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

186.18

url print :

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details of functionality :

Sodium 4-Phenylbutyrate is a histone deacetylase inhibitor that displays anticancer activity. Inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. Sodium 4-Phenylbutyrate also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of the -globin gene and affects hPPAR activation.

top caption :

Histone deacetylase inhibitor

extended description :

Histone deacetylase inhibitor

chemical name text :

4-Phenylbutyric acid, sodium salt

formula :

C10H11NaO2

formula text :

C10H11NaO2

cas num :

1716-12-7

USD :

135 USD

product details :

Histone deacetylase inhibitor

alt names :

4-PB,Sodium phenylbutyrate

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage