UCL 2077 | Tocris Bioscience 2661 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

UCL 2077

catalog :

2661

quantity :

10 mg (also 50 mg)

price :

140 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Paz R, Tubert C, Stahl A, Díaz A, Etchenique R, Murer M, et al. Inhibition of striatal cholinergic interneuron activity by the Kv7 opener retigabine and the nonsteroidal anti-inflammatory drug diclofenac. Neuropharmacology. 2018;137:309-321 pubmed publisher
Zhang L, Ouyang M, Ganellin C, Thomas S. The slow afterhyperpolarization: a target of ?1-adrenergic signaling in hippocampus-dependent memory retrieval. J Neurosci. 2013;33:5006-16 pubmed publisher

product information

brand :

Tocris

master code :

2661

SKU :

2661/10

product name :

UCL 2077

description :

Slow afterhyperpolarization (sAHP) channel blocker; sub-type selective Kv channel effects

target :

Ca2+-Activated Potassium Channel Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

350.46

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Slow afterhyperpolarization (sAHP) channel blocker; reduces sAHP in hippocampal slice preparations. Displays no effect on Ca2+ currents or the time course of sAHP/sIAHP. Exhibits potent inhibition of KCNQ1 and KCNQ2, but differential effects at other KCNQs. Rescues memory retrieval in dopamine -hydroxylase knockout mice.

catalog number base :

2661

extended description :

Slow afterhyperpolarization (sAHP) channel blocker; sub-type selective Kv channel effects

chemical name text :

N-Trityl-3-pyridinemethanamine

formula :

C 25 H 22 N 2

formula text :

C25H22N2

cas num :

918311-87-2

USD :

140 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage