Concanamycin A | Tocris Bioscience 2656/10U product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Concanamycin A

catalog :

2656/10U

quantity :

10 ug

price :

198 USD

citations: 2

Reference
Gomes da Silva L, Jimenez A, Sauvat A, Xie W, Souquere S, Divoux S, et al. Recruitment of LC3 to damaged Golgi apparatus. Cell Death Differ. 2018;: pubmed publisher
Chabaud M, Heuzé M, Bretou M, Vargas P, Maiuri P, Solanes P, et al. Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells. Nat Commun. 2015;6:7526 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

2656

SKU :

2656/10U

product name :

Concanamycin A

Description :

H+-ATPase (vacuolar) inhibitor

target :

H+-ATPase Inhibitors

category :

Small Molecules

unit size :

10 ug

purity :

90%

observed molecular weight :

866.09

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Concanamycin A is a specific inhibitor of V-type (vacuolar) H+-ATPase that displays 2000-fold selectivity over other H+-ATPases (IC50 values are 9.2, 20000, 20000 and 20000 nM for yeast V-type, F-type, P-type H+-ATPases and porcine P-type Na+,K+-ATPase respectively). Blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines.

extended description :

H+-ATPase (vacuolar) inhibitor

chemical name text :

(3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(Aminocarbonyl)-2,6-dideoxy- -D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propenyl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-9-ethyl-8,10-dihydroxy-

formula :

C 46 H 75 NO 14

formula text :

C46H75NO14

cas num :

80890-47-7

USD :

198 USD

product details :

H+-ATPase (vacuolar) inhibitor

alt names :

Folimycin

storage :

Store at -20°C