Pifithrin-mu | Tocris Bioscience 2653/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Pifithrin-mu

catalog :

2653/10

quantity :

10 mg (also 50 mg)

price :

108 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Li H, Zhang J, Niswander L. Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation. Development. 2018;145: pubmed publisher
Nemade H, Chaudhari U, Acharya A, Hescheler J, Hengstler J, Papadopoulos S, et al. Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells. Arch Toxicol. 2018;92:1507-1524 pubmed publisher
Blatzer M, Blum G, Jukic E, Posch W, Gruber P, Nagl M, et al. Blocking Hsp70 enhances the efficiency of amphotericin B treatment against resistant Aspergillus terreus strains. Antimicrob Agents Chemother. 2015;59:3778-88 pubmed publisher
Xia H, Zhang W, Li Y, Guo N, Yu C. EZH2 silencing with RNA interference induces G2/M arrest in human lung cancer cells in vitro. Biomed Res Int. 2014;2014:348728 pubmed publisher
Wang H, Wu C, Cheng T, Kuo C, Tsai Y, Chiang S, et al. Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro. Evid Based Complement Alternat Med. 2013;2013:857929 pubmed publisher
Kojima K, Burks J, Arts J, Andreeff M. The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias. Mol Cancer Ther. 2010;9:2545-57 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2653

SKU :

2653/10

product name :

Pifithrin-mu

description :

Inhibitor of p53-mitochondrial binding

target :

p53 Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at +4°C

observed molecular weight :

181.21

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Pifithrin- inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Displays no effect on the transactivational or cell cycle checkpoint control function of p53. Potentially increases reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs) by silencing p53. Pifithrin- reduces cell death induced by -radiation in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. Selectively inhibits heat shock protein 70 (HSP70) activity.

product keywords :

inhibitors inhibits p53-mitochondrial binding Transcription Factors MDM2 p14ARF Pifithrin-mu NSC303580 NSC 303580 p53 Stem Cell Reprogramming Hsp70 2653,

extended description :

Inhibitor of p53-mitochondrial binding

chemical name text :

2-Phenylethynesulfonamide

formula :

C8H7NO2S

formula text :

C8H7NO2S

cas num :

64984-31-2

USD :

119

USD 2025 :

108 USD

product details :

Inhibitor of p53-mitochondrial binding

alt names :

NSC 303580

more info or order :

Tocris Bioscience product webpage