WAY 213613 | Tocris Bioscience 2652 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

WAY 213613

catalog :

2652

quantity :

10 mg (also 50 mg)

price :

224 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Falcucci R, Wertz R, Green J, Meucci O, Salvino J, Fontana A. Novel Positive Allosteric Modulators of Glutamate Transport Have Neuroprotective Properties in an in Vitro Excitotoxic Model. ACS Chem Neurosci. 2019;10:3437-3453 pubmed publisher
Brancaccio M, Patton A, Chesham J, Maywood E, Hastings M. Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling. Neuron. 2017;93:1420-1435.e5 pubmed publisher
Dumont A, Goursaud S, Desmet N, Hermans E. Differential regulation of glutamate transporter subtypes by pro-inflammatory cytokine TNF-? in cortical astrocytes from a rat model of amyotrophic lateral sclerosis. PLoS ONE. 2014;9:e97649 pubmed publisher

product information

brand :

Tocris

master code :

2652

SKU :

2652/10

product name :

WAY 213613

description :

Potent, non-substrate EAAT2 inhibitor

target :

Glutamate (EAAT) Transporter Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

415.19

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, non-substrate inhibitor of EAAT2 (GLT-1) that displays 44-fold selectivity over EAAT1 and EAAT3 (IC50 values are 85, 3787 and 5004 nM for EAAT2, EAAT3 and EAAT1 respectively). Exhibits no activity towards ionotropic and metabotropic glutamate receptors.

catalog number base :

2652

extended description :

Potent, non-substrate EAAT2 inhibitor

chemical name text :

N-[4-(2-Bromo-4,5-difluorophenoxy)phenyl]-L-asparagine

formula :

C 16 H 13 BrF 2 N 2 O 4

formula text :

C16H13BrF2N2O4

cas num :

868359-05-1

USD :

224 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage