WAY 213613 | Tocris Bioscience 2652/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

WAY 213613

catalog :

2652/10

quantity :

10 mg (also 50 mg)

price :

302 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Falcucci R, Wertz R, Green J, Meucci O, Salvino J, Fontana A. Novel Positive Allosteric Modulators of Glutamate Transport Have Neuroprotective Properties in an in Vitro Excitotoxic Model. ACS Chem Neurosci. 2019;10:3437-3453 pubmed publisher
Brancaccio M, Patton A, Chesham J, Maywood E, Hastings M. Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling. Neuron. 2017;93:1420-1435.e5 pubmed publisher
Dumont A, Goursaud S, Desmet N, Hermans E. Differential regulation of glutamate transporter subtypes by pro-inflammatory cytokine TNF-? in cortical astrocytes from a rat model of amyotrophic lateral sclerosis. PLoS ONE. 2014;9:e97649 pubmed publisher

product information

brand :

Tocris

catalog number base :

2652

SKU :

2652/10

product name :

WAY 213613

units size :

10 mg (also 50 mg)

description :

Potent, non-substrate EAAT2 inhibitor

target :

Glutamate (EAAT) Transporter Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

415.19

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

review stars :

details of functionality :

WAY 213613 is a potent, non-substrate inhibitor of EAAT2 (GLT-1) that displays 44-fold selectivity over EAAT1 and EAAT3 (IC50 values are 85, 3787 and 5004 nM for EAAT2, EAAT3 and EAAT1 respectively). Another study has found WAY 213613 has 12 - 26-fold selectivity for EAAT2 over EAAT1, EAAT3 and EAAT4 (IC50 values are 0.071, 0.86, 1.5 and 1.9 nM for EAAT2, EAAT1, EAAT4 and EAAT3, respectively). Exhibits no activity towards ionotropic and metabotropic glutamate receptors.

top caption :

Potent, non-substrate EAAT2 inhibitor

extended description :

Potent, non-substrate EAAT2 inhibitor

chemical name text :

N-[4-(2-Bromo-4,5-difluorophenoxy)phenyl]-L-asparagine

formula :

C16H13BrF2N2O4

formula text :

C16H13BrF2N2O4

cas num :

868359-05-1

USD :

302 USD

product details :

Potent, non-substrate EAAT2 inhibitor

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage