AEG 3482 | Tocris Bioscience 2651/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AEG 3482

catalog :

2651/10

quantity :

10 mg (also 50 mg)

price :

171 USD

citations: 5

Reference
Xiao X, Lai W, Xie H, Liu Y, Guo W, Liu Y, et al. Targeting JNK pathway promotes human hematopoietic stem cell expansion. Cell Discov. 2019;5:2 pubmed publisher
Ryals M, Morell R, Martin D, Boger E, Wu P, Raible D, et al. The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity. Front Cell Neurosci. 2018;12:445 pubmed publisher
Baston Buest D, Altergot Ahmad O, Pour S, Krüssel J, Markert U, Fehm T, et al. Syndecan-1 Acts as an Important Regulator of CXCL1 Expression and Cellular Interaction of Human Endometrial Stromal and Trophoblast Cells. Mediators Inflamm. 2017;2017:8379256 pubmed publisher
Lahiri S, Lu H, Mukherjee D, Yu L, Zhao J. ERK2 phosphorylates Krüppel-like factor 8 protein at serine 48 to maintain its stability. Am J Cancer Res. 2016;6:910-23 pubmed
Roselli F, Livrea P, Almeida O. CDK5 is essential for soluble amyloid ?-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton. PLoS ONE. 2011;6:e23097 pubmed publisher

product information

brand :

Tocris

master code :

2651

SKU :

2651/10

product name :

AEG 3482

description :

Inhibitor of JNK signaling

target :

JNK/c-jun Inhibitors

category :

Small Molecules

unit sizes :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

280.33

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AEG 3482 is an inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC50 = 20 u M).

extended description :

Inhibitor of JNK signaling

chemical name text :

6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide

formula :

C 10 H 8 N 4 O 2 S 2

formula text :

C10H8N4O2S2

cas num :

63735-71-7

USD :

171 USD

product details :

Inhibitor of JNK signaling

storage :

Store at RT