SB 590885 | Tocris Bioscience 2650/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SB 590885

catalog :

2650/10

quantity :

10 mg (also 50 mg)

price :

312 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Najm F, Madhavan M, Zaremba A, Shick E, Karl R, Factor D, et al. Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo. Nature. 2015;522:216-20 pubmed publisher
Wagenaar T, Ma L, Roscoe B, Park S, Bolon D, Green M. Resistance to vemurafenib resulting from a novel mutation in the BRAFV600E kinase domain. Pigment Cell Melanoma Res. 2014;27:124-33 pubmed publisher
Balaburski G, Leu J, Beeharry N, Hayik S, Andrake M, Zhang G, et al. A modified HSP70 inhibitor shows broad activity as an anticancer agent. Mol Cancer Res. 2013;11:219-29 pubmed publisher

product information

brand :

Tocris

master code :

2650

SKU :

2650/10

product name :

SB 590885

description :

Potent B-Raf inhibitor

target :

Raf Kinase Inhibitors

category :

Small Molecules

unit sizes :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

453.54

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SB 590885 is a potent B-Raf inhibitor (Kd = 0.3 nM). Selective for B-Raf against 46 other kinases (Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively). Decreases anchorage-independent growth of melanoma cell lines. Inhibits ERK phosphorylation and proliferation in tumor cells expressing B-RafV600E. The compound can be used in protocols for the chemical reprogramming of somatic cells to iPSCs.

extended description :

Potent B-Raf inhibitor

chemical name text :

5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime

formula :

C 27 H 27 N 5 O 2

formula text :

C27H27N5O2

cas num :

405554-55-4

USD :

312 USD

product details :

Potent B-Raf inhibitor

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage