GW 9508 | Tocris Bioscience 2649/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GW 9508

catalog :

2649/10

quantity :

10 mg (also 50 mg)

price :

219 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Dragano N, Solon C, Ramalho A, de Moura R, Razolli D, Christiansen E, et al. Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation. J Neuroinflammation. 2017;14:91 pubmed publisher
Kim J, Okla M, Erickson A, Carr T, Natarajan S, Chung S. Eicosapentaenoic Acid Potentiates Brown Thermogenesis through FFAR4-dependent Up-regulation of miR-30b and miR-378. J Biol Chem. 2016;291:20551-62 pubmed publisher
Konno Y, Ueki S, Takeda M, Kobayashi Y, Tamaki M, Moritoki Y, et al. Functional analysis of free fatty acid receptor GPR120 in human eosinophils: implications in metabolic homeostasis. PLoS ONE. 2015;10:e0120386 pubmed publisher
Watson S, Brown A, Holliday N. Differential signaling by splice variants of the human free fatty acid receptor GPR120. Mol Pharmacol. 2012;81:631-42 pubmed publisher
Oh D, Talukdar S, Bae E, Imamura T, Morinaga H, Fan W, et al. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell. 2010;142:687-98 pubmed publisher

image

image 1 :

Cat.No. 2649 - GW 9508 C22H21NO3 CAS No. 885101-89-3

product information

brand :

Tocris

catalog number base :

2649

SKU :

2649/10

product name :

GW 9508

units size :

10 mg (also 50 mg)

description :

Potent and selective FFA1 (GPR40) agonist

target :

Free Fatty Acid Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

347.41

url print :

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details of functionality :

GW 9508 is a potent and selective agonist for the free fatty acid receptor FFA1 (GPR40) (pEC50 values are 7.32, 4.3 and 4.3 for FFA1, FFA2 and FFA3 receptors respectively). Inactive against a range of other GPCRs, kinases, proteases, integrins and PPARs. Potentiates glucose-stimulated insulin secretion in MIN6 cells (pEC50 = 6.14).

top caption :

Potent and selective FFA1 (GPR40) agonist

extended description :

Potent and selective FFA1 (GPR40) agonist

chemical name text :

4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid

formula :

C22H21NO3

formula text :

C22H21NO3

cas num :

885101-89-3

USD :

219 USD

product details :

Potent and selective FFA1 (GPR40) agonist

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage