L-368,899 hydrochloride | Tocris Bioscience 2641 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

L-368,899 hydrochloride

catalog :

2641

quantity :

1 mg (also 10 mg)

price :

146 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Xiao L, Priest M, Kozorovitskiy Y. Oxytocin functions as a spatiotemporal filter for excitatory synaptic inputs to VTA dopamine neurons. elife. 2018;7: pubmed publisher
Xiao L, Priest M, Nasenbeny J, Lu T, Kozorovitskiy Y. Biased Oxytocinergic Modulation of Midbrain Dopamine Systems. Neuron. 2017;95:368-384.e5 pubmed publisher
Pont J, McArdle C, Lopez Bernal A. Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells. Mol Endocrinol. 2012;26:1743-56 pubmed
Gaetani S, Fu J, Cassano T, Dipasquale P, Romano A, Righetti L, et al. The fat-induced satiety factor oleoylethanolamide suppresses feeding through central release of oxytocin. J Neurosci. 2010;30:8096-101 pubmed publisher

product information

brand :

Tocris

master code :

2641

SKU :

2641/1

product name :

L-368,899 hydrochloride

description :

Potent, non-peptide oxytocin receptor antagonist

target :

Oxytocin Receptor Antagonists

category :

Small Molecules

unit size :

1 mg (also 10 mg)

purity :

97%

observed molecular weight :

591.23

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, non-peptide and orally active oxytocin receptor antagonist (IC50 = 8.9 nM) that displays 40-fold selectivity over vasopressin V1a and V2 receptors (IC50 values are 370 and 570 nM respectively). Antagonizes oxytocin-induced uterine contractions in vitro and in vivo .

catalog number base :

2641

extended description :

Potent, non-peptide oxytocin receptor antagonist

chemical name text :

(2S)-2-Amino-N-[(1S,2S,4R)-7,7-dimethyl-1-[[[4-(2-methylphenyl)-1-piperazinyl]sulfonyl]methyl]bicyclo[2.2.1]hept-2-yl]-4-(methylsulfonyl)butanamide

formula :

C 26 H 42 N 4 O 5 S 2 .HCl

formula text :

C26H42N4O5S2.HCl

cas num :

160312-62-9

USD :

146 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage