CGK 733 | Tocris Bioscience 2639 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CGK 733

catalog :

2639

quantity :

10 mg (also 50 mg)

price :

163 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Labay E, Efimova E, Quarshie B, Golden D, Weichselbaum R, Kron S. Ionizing radiation-induced foci persistence screen to discover enhancers of accelerated senescence. Int J High Throughput Screen. 2011;2:1-13 pubmed
Shirazi Fard S, All Ericsson C, Hallböök F. The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway. Cell Cycle. 2014;13:408-17 pubmed publisher
Luo Y, Lou S, Deng X, Liu Z, Li Y, Kleiboeker S, et al. Parvovirus B19 infection of human primary erythroid progenitor cells triggers ATR-Chk1 signaling, which promotes B19 virus replication. J Virol. 2011;85:8046-55 pubmed publisher

product information

brand :

Tocris

master code :

2639

SKU :

2639/10

product name :

CGK 733

description :

Induces apoptosis in prematurely senescent cells

target :

ATM and ATR Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

555.84

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Originally defined as a selective inhibitor of ATR and ATM kinases. Induces cell death in prematurely senescent breast cancer cells. Decreases p21CIP1 levels in premature senescent MCF-7 and HCT-116 cells; also exhibits antiproliferative activity in a range of cancer cell lines. Blocks camptothecin-induced p53 phosphorylation and protects cells from camptothecin-induced apoptosis.

catalog number base :

2639

extended description :

Induces apoptosis in prematurely senescent cells

chemical name text :

-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]benzeneacetamide

formula :

C 23 H 18 Cl 3 FN 4 O 3 S

formula text :

C23H18Cl3FN4O3S

cas num :

905973-89-9

USD :

163 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage