Gliotoxin | Tocris Bioscience 2637 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Gliotoxin

catalog :

2637

quantity :

1 mg

price :

99 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Park G, Jeong J, Kim D. Gliotoxin Enhances Autophagic Cell Death via the DAPK1-TAp63 Signaling Pathway in Paclitaxel-Resistant Ovarian Cancer Cells. Mar Drugs. 2019;17: pubmed publisher

product information

brand :

Tocris

master code :

2637

SKU :

2637/1

product name :

Gliotoxin

description :

Inhibitor of 20S proteasome; immunosuppressant

target :

NFkB / IkB Inhibitors

category :

Small Molecules

unit size :

1 mg

observed molecular weight :

326.38

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Immunosuppressive agent; blocks phagocytosis, cytokine production and proliferation of T and B cells. Non-competitively inhibits chymotrypsin-like activity of 20S proteasome; prevents degradation of I B , an endogenous blocker of NF- B. Inhibits leukotriene B4 (LTB4) biosynthesis via inhibition of LTA4 hydrolase. Also inhibits farnesyltransferase and geranylgeranyltransferase I (IC50 values are 80 and 17 u M respectively) and displays antitumor activity against breast cancer in vivo .

catalog number base :

2637

extended description :

Inhibitor of 20S proteasome; immunosuppressant

chemical name text :

(3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione

formula :

C 13 H 14 N 2 O 4 S 2

formula text :

C13H14N2O4S2

cas num :

67-99-2

USD :

99 USD

alt names :

Aspergillin

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage