product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Marimastat
catalog :
2631/1
quantity :
1 mg (also 10 mg)
price :
195 USD
more info or order :
citations: 31
Reference
Wisdom K, Adebowale K, Chang J, Lee J, Nam S, Desai R, et al. Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments. Nat Commun. 2018;9:4144 pubmed publisher
Megia Fernandez A, Mills B, Michels C, Chankeshwara S, Krstajic N, Haslett C, et al. Bimodal fluorogenic sensing of matrix proteolytic signatures in lung cancer. Org Biomol Chem. 2018;16:8056-8063 pubmed publisher
Muta Y, Fujita Y, Sumiyama K, Sakurai A, Taketo M, Chiba T, et al. Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine. Nat Commun. 2018;9:2174 pubmed publisher
Fuchslocher Chico J, Falk Paulsen M, Luzius A, Saggau C, Ruder B, Bolik J, et al. The enhanced susceptibility of ADAM-17 hypomorphic mice to DSS-induced colitis is not ameliorated by loss of RIPK3, revealing an unexpected function of ADAM-17 in necroptosis. Oncotarget. 2018;9:12941-12958 pubmed publisher
Rayagiri S, Ranaldi D, Raven A, Mohamad Azhar N, Lefebvre O, Zammit P, et al. Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal. Nat Commun. 2018;9:1075 pubmed publisher
Bezenah J, Kong Y, Putnam A. Evaluating the potential of endothelial cells derived from human induced pluripotent stem cells to form microvascular networks in 3D cultures. Sci Rep. 2018;8:2671 pubmed publisher
Pitt J, Wilcox K, Tortelli V, Diniz L, Oliveira M, Dobbins C, et al. Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound A? oligomers. Mol Biol Cell. 2017;28:2623-2636 pubmed publisher
Rosner M, Pham H, Moriggl R, Hengstschlager M. Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1. Nat Commun. 2017;8:595 pubmed publisher
Trappmann B, Baker B, Polacheck W, Choi C, Burdick J, Chen C. Matrix degradability controls multicellularity of 3D cell migration. Nat Commun. 2017;8:371 pubmed publisher
Lahey K, Ronaghan N, Shang J, Dion S, Desilets A, Leduc R, et al. Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function. PLoS ONE. 2017;12:e0180259 pubmed publisher
Madoux F, Dreymüller D, Pettiloud J, Santos R, Becker Pauly C, Ludwig A, et al. Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate. Sci Rep. 2016;6:11 pubmed publisher
Nicolaou A, Zhao Z, Northoff B, Sass K, Herbst A, Kohlmaier A, et al. Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice. Arterioscler Thromb Vasc Biol. 2017;37:247-257 pubmed publisher
Kwong G, Dudani J, Carrodeguas E, Mazumdar E, Zekavat S, Bhatia S. Mathematical framework for activity-based cancer biomarkers. Proc Natl Acad Sci U S A. 2015;112:12627-32 pubmed publisher
Ji J, Jia S, Jia Y, Ji K, Hargest R, Jiang W. WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-γ pathways. Br J Cancer. 2015;113:921-33 pubmed publisher
Knapinska A, Dreymüller D, Ludwig A, Smith L, Golubkov V, Sohail A, et al. SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes. J Med Chem. 2015;58:5808-24 pubmed publisher
Zariffard M, Anastos K, French A, Munyazesa E, Cohen M, Landay A, et al. Cleavage/alteration of interleukin-8 by matrix metalloproteinase-9 in the female lower genital tract. PLoS ONE. 2015;10:e0116911 pubmed publisher
Lee C, Zhan Q, Lezcano C, Frank M, Huang J, Larson A, et al. Nestin depletion induces melanoma matrix metalloproteinases and invasion. Lab Invest. 2014;94:1382-95 pubmed publisher
Haage A, Schneider I. Cellular contractility and extracellular matrix stiffness regulate matrix metalloproteinase activity in pancreatic cancer cells. FASEB J. 2014;28:3589-99 pubmed publisher
Wang L, Cossette S, Rarick K, Gershan J, Dwinell M, Harder D, et al. Astrocytes directly influence tumor cell invasion and metastasis in vivo. PLoS ONE. 2013;8:e80933 pubmed publisher
Arruga F, Gizdić B, Serra S, Vaisitti T, Ciardullo C, Coscia M, et al. Functional impact of NOTCH1 mutations in chronic lymphocytic leukemia. Leukemia. 2014;28:1060-70 pubmed publisher
Li M, Shao J, Meng Y, Mei J, Wang Y, Li H, et al. NME1 suppression promotes growth, adhesion and implantation of endometrial stromal cells via Akt and MAPK/Erk1/2 signal pathways in the endometriotic milieu. Hum Reprod. 2013;28:2822-31 pubmed publisher
Guo Z, Jin X, Jia H. Inhibition of ADAM-17 more effectively down-regulates the Notch pathway than that of ?-secretase in renal carcinoma. J Exp Clin Cancer Res. 2013;32:26 pubmed publisher
Fan H, Zhao X, Sun S, Luo M, Guan J. Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo. J Biol Chem. 2013;288:3322-33 pubmed publisher
Brafman D, Phung C, Kumar N, Willert K. Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. Cell Death Differ. 2013;20:369-81 pubmed publisher
Yurtsever Z, Sala Rabanal M, Randolph D, Scheaffer S, Roswit W, Alevy Y, et al. Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation. J Biol Chem. 2012;287:42138-49 pubmed publisher
Le Friec G, Sheppard D, Whiteman P, Karsten C, Shamoun S, Laing A, et al. The CD46-Jagged1 interaction is critical for human TH1 immunity. Nat Immunol. 2012;13:1213-21 pubmed publisher
Mezil L, Berruyer Pouyet C, Cabaud O, Josselin E, Combes S, Brunel J, et al. Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer. PLoS ONE. 2012;7:e43409 pubmed publisher
Prendergast A, Linbo T, Swarts T, Ungos J, McGraw H, Krispin S, et al. The metalloproteinase inhibitor Reck is essential for zebrafish DRG development. Development. 2012;139:1141-52 pubmed publisher
Kachgal S, Carrion B, Janson I, Putnam A. Bone marrow stromal cells stimulate an angiogenic program that requires endothelial MT1-MMP. J Cell Physiol. 2012;227:3546-55 pubmed publisher
Kachgal S, Putnam A. Mesenchymal stem cells from adipose and bone marrow promote angiogenesis via distinct cytokine and protease expression mechanisms. Angiogenesis. 2011;14:47-59 pubmed publisher
Ghajar C, Kachgal S, Kniazeva E, Mori H, Costes S, George S, et al. Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms. Exp Cell Res. 2010;316:813-25 pubmed publisher
product information
brand :
Tocris
catalog number base :
2631
SKU :
2631/1
product name :
Marimastat
units size :
1 mg (also 10 mg)
description :
Broad spectrum MMP inhibitor
target :
Synthetic Metalloprotease Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
331.41
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
review stars :
5
details of functionality :
Marimastat is a broad spectrum inhibitor of MMPs (IC50 values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). Inhibits peritoneal dissemination of human gastric cancer cells in vivo through inhibition of tumor angiogenesis.
top caption :
Broad spectrum MMP inhibitor
extended description :
Broad spectrum MMP inhibitor
chemical name text :
(2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide
formula :
C15H29N3O5
formula text :
C15H29N3O5
cas num :
154039-60-8
USD :
195 USD
product details :
Broad spectrum MMP inhibitor
alt names :
BB 2516,Marimistat
storage :
Store at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK