L-685,458 | Tocris Bioscience 2627 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

L-685,458

catalog :

2627

quantity :

1 mg

price :

284 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Kaylan K, Berg I, Biehl M, Brougham Cook A, Jain I, Jamil S, et al. Spatial patterning of liver progenitor cell differentiation mediated by cellular contractility and Notch signaling. elife. 2018;7: pubmed publisher
Liu C, Zhang C, Zhou Y, Wong W, Lee L, Ong W, et al. APP upregulation contributes to retinal ganglion cell degeneration via JNK3. Cell Death Differ. 2018;25:661-676 pubmed publisher
Chai Q, Jovasevic V, Malikov V, Sabo Y, MORHAM S, Walsh D, et al. HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration. Nat Commun. 2017;8:1522 pubmed publisher
Ran Y, Ladd G, Ceballos Diaz C, Jung J, Greenbaum D, Felsenstein K, et al. Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors. PLoS ONE. 2015;10:e0128619 pubmed publisher
Greife A, Jankowiak S, Steinbring J, Nikpour P, Niegisch G, Hoffmann M, et al. Canonical Notch signalling is inactive in urothelial carcinoma. BMC Cancer. 2014;14:628 pubmed publisher
Origlia N, Criscuolo C, Arancio O, Yan S, Domenici L. RAGE inhibition in microglia prevents ischemia-dependent synaptic dysfunction in an amyloid-enriched environment. J Neurosci. 2014;34:8749-60 pubmed publisher
Ran Y, Cruz P, Ladd T, Fauq A, Jung J, Matthews J, et al. ?-Secretase processing and effects of ?-secretase inhibitors and modulators on long A? peptides in cells. J Biol Chem. 2014;289:3276-87 pubmed publisher
Williams C, Segarra M, Sierra M, Sainson R, Tosato G, Harris A. Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells. Cancer Res. 2008;68:1889-95 pubmed publisher

product information

brand :

Tocris

master code :

2627

SKU :

2627/1

product name :

L-685,458

description :

Potent and selective -secretase inhibitor

target :

Secretase Inhibitors

category :

Small Molecules

unit size :

1 mg

purity :

97%

observed molecular weight :

672.85

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective -secretase inhibitor (IC50 = 17 nM) that displays 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of A 40 and A 42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro .

catalog number base :

2627

extended description :

Potent and selective -secretase inhibitor

chemical name text :

(5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucy-L-phenylalaninamide

formula :

C 39 H 52 N 4 O 6

formula text :

C39H52N4O6

cas num :

292632-98-5

USD :

284 USD

alt names :

L 458

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage