L-685,458 | Tocris Bioscience 2627/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

L-685,458

catalog :

2627/1

quantity :

1 mg

price :

387 USD

more info or order :

Tocris Bioscience product webpage

citations: 14

Reference
Mentrup T, Stumpff Niggemann A, Leinung N, Schlosser C, Schubert K, Wehner R, et al. Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis. Nat Commun. 2022;13:1880 pubmed publisher
Kaylan K, Berg I, Biehl M, Brougham Cook A, Jain I, Jamil S, et al. Spatial patterning of liver progenitor cell differentiation mediated by cellular contractility and Notch signaling. elife. 2018;7: pubmed publisher
Liu C, Zhang C, Zhou Y, Wong W, Lee L, Ong W, et al. APP upregulation contributes to retinal ganglion cell degeneration via JNK3. Cell Death Differ. 2018;25:661-676 pubmed publisher
Chai Q, Jovasevic V, Malikov V, Sabo Y, MORHAM S, Walsh D, et al. HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration. Nat Commun. 2017;8:1522 pubmed publisher
Talamillo A, Grande L, Ruiz OntaÃ±on P, Velasquez C, Mollinedo P, Torices S, et al. ODZ1 allows glioblastoma to sustain invasiveness through a Myc-dependent transcriptional upregulation of RhoA. Oncogene. 2017;36:1733-1744 pubmed publisher
Saxena P, Heng B, Bai P, Folcher M, Zulewski H, Fussenegger M. A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells. Nat Commun. 2016;7:11247 pubmed publisher
Ran Y, Ladd G, Ceballos Diaz C, Jung J, Greenbaum D, Felsenstein K, et al. Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors. PLoS ONE. 2015;10:e0128619 pubmed publisher
Maury Y, CÃ´me J, Piskorowski R, Salah Mohellibi N, Chevaleyre V, Peschanski M, et al. Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes. Nat Biotechnol. 2015;33:89-96 pubmed publisher
Greife A, Jankowiak S, Steinbring J, Nikpour P, Niegisch G, Hoffmann M, et al. Canonical Notch signalling is inactive in urothelial carcinoma. BMC Cancer. 2014;14:628 pubmed publisher
Origlia N, Criscuolo C, Arancio O, Yan S, Domenici L. RAGE inhibition in microglia prevents ischemia-dependent synaptic dysfunction in an amyloid-enriched environment. J Neurosci. 2014;34:8749-60 pubmed publisher
Ran Y, Cruz P, Ladd T, Fauq A, Jung J, Matthews J, et al. ?-Secretase processing and effects of ?-secretase inhibitors and modulators on long A? peptides in cells. J Biol Chem. 2014;289:3276-87 pubmed publisher
Csaszar E, Wang W, Usenko T, Qiao W, Delaney C, Bernstein I, et al. Blood stem cell fate regulation by Delta-1-mediated rewiring of IL-6 paracrine signaling. Blood. 2014;123:650-8 pubmed publisher
Nakajima C, Kulik A, Frotscher M, Herz J, Schafer M, Bock H, et al. Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes. J Biol Chem. 2013;288:21909-23 pubmed publisher
Williams C, Segarra M, Sierra M, Sainson R, Tosato G, Harris A. Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells. Cancer Res. 2008;68:1889-95 pubmed publisher

product information

brand :

Tocris

catalog number base :

2627

SKU :

2627/1

product name :

L-685,458

units size :

1 mg

description :

Potent and selective -secretase inhibitor

target :

Secretase Inhibitors

category :

Small Molecules

purity :

97%

observed molecular weight :

672.85

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

L-685,458 is a potent and selective -secretase inhibitor (IC50 = 17 nM) that displays 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. L-685,458 binds with high affinity to the related aspartyl protease, signal peptide peptidase (SPP; KD = 5.1 nM), and inhibits SPP expressed in HEK293 cells (IC50 = 10 M). L-685,458 exhibits equal potency for inhibition of A 40 and A 42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells). It also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro .

top caption :

Potent and selective -secretase inhibitor

extended description :

Potent and selective -secretase inhibitor

chemical name text :

(5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucy-L-phenylalaninamide

formula :

C39H52N4O6

formula text :

C39H52N4O6

cas num :

292632-98-5

USD :

387 USD

product details :

Potent and selective -secretase inhibitor

alt names :

L 458, -Secretase Inhibitor X

storage :

Store at -20Â°C

more info or order :

Tocris Bioscience product webpage