Decitabine | Tocris Bioscience 2624 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Decitabine

catalog :

2624

quantity :

10 mg (also 50 mg)

price :

157 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Kottakis F, Nicolay B, Roumane A, Karnik R, Gu H, Nagle J, et al. LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature. 2016;539:390-395 pubmed publisher
Vendetti F, Topper M, Huang P, Dobromilskaya I, Easwaran H, Wrangle J, et al. Evaluation of azacitidine and entinostat as sensitization agents to cytotoxic chemotherapy in preclinical models of non-small cell lung cancer. Oncotarget. 2015;6:56-70 pubmed
Gu X, Hu Z, Ebrahem Q, Crabb J, Mahfouz R, Radivoyevitch T, et al. Runx1 regulation of Pu.1 corepressor/coactivator exchange identifies specific molecular targets for leukemia differentiation therapy. J Biol Chem. 2014;289:14881-95 pubmed publisher
Wang N, Eckert K, Zomorrodi A, Xin P, Pan W, Shearer D, et al. Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways. PLoS ONE. 2012;7:e39446 pubmed publisher
Trowbridge J, Sinha A, Zhu N, Li M, Armstrong S, Orkin S. Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. Genes Dev. 2012;26:344-9 pubmed publisher
Perera F, Tang W, Herbstman J, Tang D, Levin L, Miller R, et al. Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. PLoS ONE. 2009;4:e4488 pubmed publisher

product information

brand :

Tocris

master code :

2624

SKU :

2624/10

product name :

Decitabine

description :

DNA methyltransferase inhibitor

target :

Methyltransferase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

228.21

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation.

catalog number base :

2624

extended description :

DNA methyltransferase inhibitor

chemical name text :

4-Amino-1-(2-deoxy- -D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one

formula :

C 8 H 12 N 4 O 4

formula text :

C8H12N4O4

cas num :

2353-33-5

USD :

157 USD

alt names :

2 -Deoxy-5-azacytidine, 5-Aza-2 -deoxycytidine, NSC 127716

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage