Decitabine | Tocris Bioscience 2624/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Decitabine

catalog :

2624/10

quantity :

10 mg (also 50 mg)

price :

210 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Kottakis F, Nicolay B, Roumane A, Karnik R, Gu H, Nagle J, et al. LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature. 2016;539:390-395 pubmed publisher
Park H, Choi Y, Kim J, Chun H, Im I, Yoon S, et al. Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes. PLoS ONE. 2015;10:e0132992 pubmed publisher
Vendetti F, Topper M, Huang P, Dobromilskaya I, Easwaran H, Wrangle J, et al. Evaluation of azacitidine and entinostat as sensitization agents to cytotoxic chemotherapy in preclinical models of non-small cell lung cancer. Oncotarget. 2015;6:56-70 pubmed
Gu X, Hu Z, Ebrahem Q, Crabb J, Mahfouz R, Radivoyevitch T, et al. Runx1 regulation of Pu.1 corepressor/coactivator exchange identifies specific molecular targets for leukemia differentiation therapy. J Biol Chem. 2014;289:14881-95 pubmed publisher
Wang N, Eckert K, Zomorrodi A, Xin P, Pan W, Shearer D, et al. Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways. PLoS ONE. 2012;7:e39446 pubmed publisher
Trowbridge J, Sinha A, Zhu N, Li M, Armstrong S, Orkin S. Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. Genes Dev. 2012;26:344-9 pubmed publisher
Perera F, Tang W, Herbstman J, Tang D, Levin L, Miller R, et al. Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. PLoS ONE. 2009;4:e4488 pubmed publisher

product information

brand :

Tocris

catalog number base :

2624

SKU :

2624/10

product name :

Decitabine

units size :

10 mg (also 50 mg)

description :

DNA methyltransferase inhibitor

target :

Methyltransferase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

228.21

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

review stars :

details of functionality :

Decitabine is a cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation. Enables generation of Chemically Induced Pluripotent Stem Cells (CiPSCs) from mouse embryonic fibroblasts (MEFs) (see protocol below). . For more information about how Decitabine may be used, see our protocol: Highly Efficient Generation of CiPSCs from MEFs

top caption :

DNA methyltransferase inhibitor

extended description :

DNA methyltransferase inhibitor

chemical name text :

4-Amino-1-(2-deoxy- -D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one

formula :

C8H12N4O4

formula text :

C8H12N4O4

cas num :

2353-33-5

USD :

210 USD

product details :

DNA methyltransferase inhibitor

alt names :

2 -Deoxy-5-azacytidine,5-Aza-2 -deoxycytidine,NSC 127716

storage :

Store at +4Â°C

more info or order :

Tocris Bioscience product webpage