Oxaliplatin | Tocris Bioscience 2623 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Oxaliplatin

catalog :

2623

quantity :

50 mg

price :

145 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Massey A. Multiparametric Cell Cycle Analysis Using the Operetta High-Content Imager and Harmony Software with PhenoLOGIC. PLoS ONE. 2015;10:e0134306 pubmed publisher
Fukushima K, Tsuchiya K, Kano Y, Horita N, Hibiya S, Hayashi R, et al. Atonal homolog 1 protein stabilized by tumor necrosis factor Î± induces high malignant potential in colon cancer cell line. Cancer Sci. 2015;106:1000-7 pubmed publisher
Li N, Lorenzi F, Kalakouti E, Normatova M, Babaei Jadidi R, Tomlinson I, et al. FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15. Oncotarget. 2015;6:9240-56 pubmed
Bryant C, Rawlinson R, Massey A. Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers. BMC Cancer. 2014;14:570 pubmed publisher
Rawlinson R, Massey A. ?H2AX and Chk1 phosphorylation as predictive pharmacodynamic biomarkers of Chk1 inhibitor-chemotherapy combination treatments. BMC Cancer. 2014;14:483 pubmed publisher
Ibáñez G, Shum D, Blum G, Bhinder B, Radu C, Antczak C, et al. A high throughput scintillation proximity imaging assay for protein methyltransferases. Comb Chem High Throughput Screen. 2012;15:359-71 pubmed
Boyette Davis J, Dougherty P. Protection against oxaliplatin-induced mechanical hyperalgesia and intraepidermal nerve fiber loss by minocycline. Exp Neurol. 2011;229:353-7 pubmed publisher

product information

brand :

Tocris

master code :

2623

SKU :

2623/50

product name :

Oxaliplatin

description :

DNA cross-linking antitumor agent

target :

Apoptosis Inducer Compounds

category :

Small Molecules

unit size :

50 mg

purity :

99%

observed molecular weight :

397.29

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Displays higher cytotoxicity and lower nephrotoxicity than analog cisplatin (Cat. No. 2251) and shows antitumor activity in cell lines with acquired cisplatin resistance.

catalog number base :

2623

extended description :

DNA cross-linking antitumor agent

chemical name text :

Oxalato[(1R-trans)-1,2-cyclohexanediamine]platinum(II)

formula :

C 8 H 14 N 2 O 4 Pt

formula text :

C8H14N2O4Pt

cas num :

61825-94-3

USD :

145 USD

alt names :

Eloxatin

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage