PD 158780 | Tocris Bioscience 2615/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PD 158780

catalog :

2615/10

quantity :

10 mg (also 50 mg)

price :

246 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Matsuoka R, Marass M, Avdesh A, Helker C, Maischein H, Grosse A, et al. Radial glia regulate vascular patterning around the developing spinal cord. elife. 2016;5: pubmed publisher
Ledonne A, Nobili A, Latagliata E, Cavallucci V, Guatteo E, Puglisi Allegra S, et al. Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons. Mol Psychiatry. 2015;20:959-73 pubmed publisher

image

image 1 :

Cat.No. 2615 - PD 158780 C14H12BrN5 CAS No. 171179-06-9

product information

brand :

Tocris

master code :

2615

SKU :

2615/10

product name :

PD 158780

description :

Potent ErbB receptor family inhibitor

target :

EGF Receptor Inhibitors

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

330.18

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PD 158780 is a potent inhibitor of ErbB receptor family tyrosine kinases (IC50 values are 0.008, 49 and 52 nM for EGFR, ErbB2 and ErbB2/ErbB4 respectively) that does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells.

extended description :

Potent ErbB receptor family inhibitor

chemical name text :

N4-(3-Bromophenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine

formula :

C 14 H 12 BrN 5

formula text :

C14H12BrN5

cas num :

171179-06-9

USD :

234

USD 2023 :

246 USD

product details :

Potent ErbB receptor family inhibitor

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage