RWJ 56110 | Tocris Bioscience 2614 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

RWJ 56110

catalog :

2614

quantity :

1 mg

price :

197 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Shi Y, Hung S, Rocha G, Lin S, Linares G, Staats K, et al. Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons. JCI Insight. 2019;5: pubmed publisher
Wang H, Ricklin D, Lambris J. Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4. Proc Natl Acad Sci U S A. 2017;114:10948-10953 pubmed publisher
Xu Q, Liu J, WANG Z, Guo X, Zhou G, Liu Y, et al. Heat stress-induced disruption of endothelial barrier function is via PAR1 signaling and suppressed by Xuebijing injection. PLoS ONE. 2015;10:e0118057 pubmed publisher
Eum S, Jaraki D, Bertrand L, Andras I, Toborek M. Disruption of epithelial barrier by quorum-sensing N-3-(oxododecanoyl)-homoserine lactone is mediated by matrix metalloproteinases. Am J Physiol Gastrointest Liver Physiol. 2014;306:G992-G1001 pubmed publisher
Juncker Jensen A, Deryugina E, Rimann I, Zajac E, Kupriyanova T, Engelholm L, et al. Tumor MMP-1 activates endothelial PAR1 to facilitate vascular intravasation and metastatic dissemination. Cancer Res. 2013;73:4196-211 pubmed publisher

image

image 1 :

Cat.No. 2614 - RWJ 56110 C41H43Cl2F2N7O3.2HCl

product information

brand :

Tocris

master code :

2614

SKU :

2614/1

product name :

RWJ 56110

description :

Selective PAR1 antagonist

target :

Protease-Activated Receptor Antagonists

category :

Small Molecules

unit size :

1 mg

purity :

96%

observed molecular weight :

863.65

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective protease-activated receptor-1 (PAR1) antagonist; displays no activity at PAR2, PAR3, or PAR4 subtypes. Blocks thrombin-induced platelet aggregation and activation of MAPK in HUVECs. Also inhibits angiogenesis in a chick embryo angiogenesis model in vivo .

catalog number base :

2614

extended description :

Selective PAR1 antagonist

chemical name text :

( S)-N-[(1S)-3-Amino-1-[[(phenylmethyl)amino]carbonyl]propyl]- -[[[[1-[(2,6-dichlorophenyl)methyl]-3-(1-pyrrolidinylmethyl)-1H-indol-6-yl]amino]carbonyl]amino]-3,4-difluoro-benzenepropanamide

formula :

C 41 H 43 Cl 2 F 2 N 7 O 3 .2HCl

formula text :

C41H43Cl2F2N7O3.2HCl

USD :

197 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage