NSC 87877 | Tocris Bioscience 2613/50 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NSC 87877

catalog :

2613/50

quantity :

50 mg

price :

202 USD

citations: 8

Reference
Zhang B, Lu W. Src homology 2 domain-containing phosphotyrosine phosphatase 2 (Shp2) controls surface GluA1 protein in synaptic homeostasis. J Biol Chem. 2017;292:15481-15488 pubmed publisher
Kim A, Ulirsch J, Wilmes S, Unal E, Moraga I, Karakukcu M, et al. Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation. Cell. 2017;168:1053-1064.e15 pubmed publisher
Zhang B, Du Y, Lu W, Yan X, Yang Q, Yang W, et al. Increased Activity of Src Homology 2 Domain Containing Phosphotyrosine Phosphatase 2 (Shp2) Regulates Activity-dependent AMPA Receptor Trafficking. J Biol Chem. 2016;291:18856-66 pubmed publisher
Taylor A, Harker J, Chanthong K, Stevenson P, Zuniga E, Rudd C. Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses. Immunity. 2016;44:274-86 pubmed publisher
Pinzon Guzman C, Xing T, Zhang S, Barnstable C. Regulation of rod photoreceptor differentiation by STAT3 is controlled by a tyrosine phosphatase. J Mol Neurosci. 2015;55:152-159 pubmed publisher
Quintanar Audelo M, Yusoff P, Sinniah S, Chandramouli S, Guy G. Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain-containing protein (SPRED1), a tyrosine-protein phosphatase non-receptor type 11 (SHP2) substrate in the Ras/extracellular signal-regulated kinase (ERK) pathway. J Biol Chem. 2011;286:23102-12 pubmed publisher
Abeyweera T, Merino E, Huse M. Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells. J Cell Biol. 2011;192:675-90 pubmed publisher
Fragale A, Stellacci E, Ilari R, Remoli A, Lanciotti A, Perrotti E, et al. Critical role of IRF-8 in negative regulation of TLR3 expression by Src homology 2 domain-containing protein tyrosine phosphatase-2 activity in human myeloid dendritic cells. J Immunol. 2011;186:1951-62 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

2613

SKU :

2613/50

product name :

NSC 87877

Description :

Potent inhibitor of shp2 and shp1 PTP

target :

Protein Tyrosine Phosphatase Inhibitors

category :

Small Molecules

unit size :

50 mg

purity :

98%

observed molecular weight :

459.45

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NSC 87877 is a potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 u M for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.

extended description :

Potent inhibitor of shp2 and shp1 PTP

chemical name text :

8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonic acid

formula :

C 19 H 13 N 3 O 7 S 2

formula text :

C19H13N3O7S2

cas num :

56990-57-9

USD :

202 USD

product details :

Potent inhibitor of shp2 and shp1 PTP

storage :

Store at +4°C