IMD 0354 | Tocris Bioscience 2611/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

IMD 0354

catalog :

2611/10

quantity :

10 mg (also 50 mg)

price :

176 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Zhang D, Li L, Jiang H, Li Q, Wang Gillam A, Yu J, et al. Tumor-Stroma IL1β-IRAK4 Feedforward Circuitry Drives Tumor Fibrosis, Chemoresistance, and Poor Prognosis in Pancreatic Cancer. Cancer Res. 2018;78:1700-1712 pubmed publisher
Cataldi M, Shah N, Felt S, Grdzelishvili V. Breaking resistance of pancreatic cancer cells to an attenuated vesicular stomatitis virus through a novel activity of IKK inhibitor TPCA-1. Virology. 2015;485:340-54 pubmed publisher
Kong X, Duan L, Qian X, Xu D, Liu H, Zhu Y, et al. Tumor-suppressive microRNA-497 targets IKKÎ² to regulate NF-ÎºB signaling pathway in human prostate cancer cells. Am J Cancer Res. 2015;5:1795-804 pubmed
Zwicker S, Martinez G, Bosma M, Gerling M, Clark R, Majster M, et al. Interleukin 34: a new modulator of human and experimental inflammatory bowel disease. Clin Sci (Lond). 2015;129:281-90 pubmed publisher
Chen Y, Chiang W, Yang Y, Lai C, Wu K, Lin S. Pentoxifylline Attenuates Proteinuria in Anti-Thy1 Glomerulonephritis via Downregulation of Nuclear Factor-?B and Smad2/3 Signaling. Mol Med. 2015;21:276-84 pubmed publisher

product information

brand :

Tocris

SKU :

2611/10

product name :

IMD 0354

unit sizes :

10 mg (also 50 mg)

description :

Inhibitor of IKK

target :

IkB Kinase Inhibitors

category :

Small Molecules

purity :

99%

observed molecular weight :

383.67

details of functionality :

Inhibitor of I B kinase- (IKK ) that blocks NF- B nuclear translocation. Attenuates myocardial ischemia/reperfusion injury by decreasing expression of adhesion molecules ICAM-1 and P-selectin and inhibiting cytokine and chemokine production in cardiomyocytes. Induces G0/G1 cell cycle arrest and apoptosis in HMC-1 and breast cancer cells.

catalog number base :

2611

extended description :

Inhibitor of IKK

chemical name text :

N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide

formula :

C 15 H 8 ClF 6 NO 2

formula text :

C15H8ClF6NO2

cas num :

978-62-1

USD :

176 USD

product details :

Inhibitor of IKK

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage