17-DMAG hydrochloride | Tocris Bioscience 2610 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

17-DMAG hydrochloride

catalog :

2610

quantity :

1 mg

price :

255 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Young C, Sinadinos A, Lefebvre A, Chan P, Arkle S, Vaudry D, et al. A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90. Autophagy. 2015;11:113-30 pubmed publisher
Dote H, Burgan W, Camphausen K, Tofilon P. Inhibition of hsp90 compromises the DNA damage response to radiation. Cancer Res. 2006;66:9211-20 pubmed

product information

brand :

Tocris

master code :

2610

SKU :

2610/1

product name :

17-DMAG hydrochloride

description :

Water-soluble Hsp90 inhibitor

target :

HSP90 Inhibitors

category :

Small Molecules

unit size :

1 mg

main entrez gene id :

3320

purity :

99%

observed molecular weight :

653.21

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Water-soluble analog of 17-AAG (Cat. No. 1515) and geldanamycin (Cat. No. 1368). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).

catalog number base :

2610

product keywords :

Water-soluble Hsp90 inhibitors inhibits Heat Shock Protein 90 NSC707545 antibiotics NSC 707545 Hsp90 Antibiotics 2610,

extended description :

Water-soluble Hsp90 inhibitor

chemical name text :

17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin hydrochloride

formula :

C 32 H 48 N 4 O 8 .HCl

formula text :

C32H48N4O8.HCl

cas num :

467214-21-7

2020 USD :

247

2021 USD :

255 USD

alt names :

NSC 707545

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage