2609/10 | Tocris Bioscience 2609/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

2609/10

catalog :

2609/10

quantity :

10 mg (also 50 mg)

price :

235 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Coussens N, Kales S, Henderson M, Lee O, Horiuchi K, Wang Y, et al. High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2. J Biol Chem. 2018;293:13750-13765 pubmed publisher
FitzGerald J, Murillo L, O Brien G, O Connell E, O Connor A, Wu K, et al. A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response. PLoS ONE. 2014;9:e98891 pubmed publisher

image

image 1 :

Cat.No. 2609 - Ryuvidine C15H12N2O2S CAS No. 265312-55-8

product information

master code :

2609

SKU :

2609/10

product name :

Ryuvidine

unit size :

10 mg (also 50 mg)

description :

SETD8 inhibitor; also CDK4 inhibitor

target :

Lysine Methyltransferase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

284.33

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Ryuvidine is an inhibitor of SETD8 protein lysine methyltransferase (PKMT) (IC50 = 0.5 M); suppresses H4K20 monomethylation in vitro . Also inhibits cyclin-dependent kinase (CDK) 4 (IC50 = 6.0 u M at CDK4/cyclin D1). Induces S phase accumulation in HEK293T cells. Cytotoxic against a range of human cancer cells.

top caption :

SETD8 inhibitor; also CDK4 inhibitor

extended description :

SETD8 inhibitor; also CDK4 inhibitor

chemical name text :

2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione

formula :

C15H12N2O2S

formula text :

C15H12N2O2S

cas num :

265312-55-8

USD :

235 USD

product details :

SETD8 inhibitor; also CDK4 inhibitor

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage