PD 198306 | Tocris Bioscience 2605 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PD 198306

catalog :

2605

quantity :

10 mg

price :

320 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Liddell J, Lehtonen S, Duncan C, Keksa Goldsteine V, Levonen A, Goldsteins G, et al. Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. J Neuroinflammation. 2016;13:49 pubmed publisher
Ripple M, Kim N, Springett R. Acute mitochondrial inhibition by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) 1/2 inhibitors regulates proliferation. J Biol Chem. 2013;288:2933-40 pubmed publisher

product information

brand :

Tocris

master code :

2605

SKU :

2605/10

product name :

PD 198306

description :

Selective inhibitor of MEK1/2

target :

MEK Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

476.23

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent inhibitor of MEK1/2. Inhibits isolated enzyme at a concentration of 8 nM and inhibits MEK activity in synovial fibroblasts at concentrations of 30 - 100 nM. Highly selective for MEK; IC50 values are 1, 4, 4 and 10 u M for ERK, c-Src, cdks and PI 3-kinase respectively. Antihyperalgesic; blocks static allodynia in the streptozocin model of neuropathic pain following i.t. administration.

catalog number base :

2605

product keywords :

Selective inhibitors inhibits MEK1/2 Mitogen-Activated Protein Kinase kinases PD198306 MEK 2605,

extended description :

Selective inhibitor of MEK1/2

chemical name text :

N-(Cyclopropylmethoxy)-3,4,5-trifluoro-2-[(4-iodo-2-methylphenyl)amino]-benzamide

formula :

C 18 H 16 F 3 IN 2 O 2

formula text :

C18H16F3IN2O2

cas num :

212631-61-3

2020 USD :

307

2021 USD :

320 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage