2602/10 | Tocris Bioscience 2602/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

2602/10

catalog :

2602/10

quantity :

10 mg

price :

401 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Atkins N, Mitchell J, Romanova E, Morgan D, Cominski T, Ecker J, et al. Circadian integration of glutamatergic signals by little SAAS in novel suprachiasmatic circuits. PLoS ONE. 2010;5:e12612 pubmed publisher
GonzÃ¡lez N, Mantey S, Pradhan T, Sancho V, Moody T, Coy D, et al. Characterization of putative GRP- and NMB-receptor antagonist's interaction with human receptors. Peptides. 2009;30:1473-86 pubmed publisher

product information

master code :

2602

SKU :

2602/10

product name :

PD 176252

unit size :

10 mg

description :

GRP (BB2) and NMB (BB1) receptor antagonist

target :

Bombesin Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

584.67

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PD 176252 is a non-peptide gastrin-releasing peptide receptor (GRP-R, BB2) and neuromedin B receptor (NMB-R, BB1) antagonist (Ki values are 0.17 and 1.0 nM for BB1 and BB2 respectively). Inhibits proliferation of rat C6 glioma cells (IC50 = 2 u M) and inhibits NCI-H1299 xenograft proliferation in nude mice (IC50 = 5 u M).

top caption :

GRP (BB2) and NMB (BB1) receptor antagonist

extended description :

GRP (BB2) and NMB (BB1) receptor antagonist

chemical name text :

(S)-N-[[1-(5-Methoxy-2-pyridinyl)cyclohexyl]methyl]- -methyl- -[[[-(4-nitrophenyl)amino]carbonyl]amino-1H-indole-3-propanamide

formula :

C32H36N6O5

formula text :

C32H36N6O5

cas num :

204067-01-6

USD :

401 USD

product details :

GRP (BB2) and NMB (BB1) receptor antagonist

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage