Clofarabine | Tocris Bioscience 2600 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Clofarabine

catalog :

2600

quantity :

25 mg

price :

432 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Xie C, Edwards H, Lograsso S, Buck S, Matherly L, Taub J, et al. Valproic acid synergistically enhances the cytotoxicity of clofarabine in pediatric acute myeloid leukemia cells. Pediatr Blood Cancer. 2012;59:1245-51 pubmed publisher

product information

brand :

Tocris

master code :

2600

SKU :

2600/25

product name :

Clofarabine

description :

Deoxycytidine kinase (dCK) substrate

target :

Kinase Substrates

category :

Small Molecules

unit size :

25 mg

purity :

99%

observed molecular weight :

303.68

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase- and - and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.

catalog number base :

2600

product keywords :

Deoxycytidine kinases dCK Enzyme Substrates activators antimetabolites chemotherapeutics Enzyme Substrates/ Activators Other Kinases 2600,

extended description :

Deoxycytidine kinase (dCK) substrate

chemical name text :

2-Chloro-9-(2-deoxy-2-fluoro- -D-arabinofuranosyl)-9H-purin-6-amine

formula :

C 10 H 11 ClFN 5 O 3

formula text :

C10H11ClFN5O3

cas num :

123318-82-1

2020 USD :

415

2021 USD :

432 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage