Clofarabine | Tocris Bioscience 2600/5 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Clofarabine

catalog :

2600/5

quantity :

5 mg (also 25 mg)

price :

129 USD

citations: 1

Reference
Xie C, Edwards H, Lograsso S, Buck S, Matherly L, Taub J, et al. Valproic acid synergistically enhances the cytotoxicity of clofarabine in pediatric acute myeloid leukemia cells. Pediatr Blood Cancer. 2012;59:1245-51 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2600

SKU :

2600/5

product name :

Clofarabine

description :

Deoxycytidine kinase (dCK) substrate

target :

Kinase Substrates

unit size :

5 mg (also 25 mg)

category :

Small Molecules

purity :

99%

storage :

Store at +4°C

observed molecular weight :

303.68

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Clofarabine is a deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase- and - and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.

product keywords :

Deoxycytidine kinases dCK Enzyme Substrates activators antimetabolites chemotherapeutics Enzyme Substrates/ Activators Other Kinases 2600,

extended description :

Deoxycytidine kinase (dCK) substrate

chemical name text :

2-Chloro-9-(2-deoxy-2-fluoro- -D-arabinofuranosyl)-9H-purin-6-amine

formula :

C10H11ClFN5O3

formula text :

C10H11ClFN5O3

cas num :

123318-82-1

USD :

143

USD 2025 :

129 USD

product details :

Deoxycytidine kinase (dCK) substrate