2595/1 | Tocris Bioscience 2595/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

2595/1

catalog :

2595/1

quantity :

1 mg (also 10 mg, 50 mg)

price :

137 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Ansari M, Nadeem A, Attia S, Bakheet S, Shahid M, Rehman M, et al. CCR1 antagonist J-113863 corrects the imbalance of pro- and anti-inflammatory cytokines in a SJL/J mouse model of relapsing-remitting multiple sclerosis. Immunobiology. 2022;227:152245 pubmed publisher
Kamata T, Jin H, Giblett S, Patel B, Patel F, Foster C, et al. The cholesterol-binding protein NPC2 restrains recruitment of stromal macrophage-lineage cells to early-stage lung tumours. EMBO Mol Med. 2015;7:1119-37 pubmed publisher
Rowe G, Raghuram S, Jang C, Nagy J, Patten I, Goyal A, et al. PGC-1? induces SPP1 to activate macrophages and orchestrate functional angiogenesis in skeletal muscle. Circ Res. 2014;115:504-17 pubmed publisher
Gibon E, Yao Z, Rao A, Zwingenberger S, Batke B, Valladares R, et al. Effect of a CCR1 receptor antagonist on systemic trafficking of MSCs and polyethylene particle-associated bone loss. Biomaterials. 2012;33:3632-8 pubmed publisher

product information

master code :

2595

SKU :

2595/1

product name :

J 113863

unit size :

1 mg (also 10 mg, 50 mg)

description :

Potent CCR1 chemokine receptor antagonist

target :

Chemokine Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

655.44

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

J 113863 is a potent chemokine receptor 1 (CCR1) antagonist (IC50 values are 0.9 and 5.8 nM for human and mouse CCR1 receptors respectively). Also displays high selectivity for human but not mouse CCR3 receptors (IC50 values are 0.58 and 460 nM respectively). Improves paw inflammation, joint damage and dramatically reduces cell infiltration into joints in collagen-induced arthritis in mice. . Isomer also available.

top caption :

Potent CCR1 chemokine receptor antagonist

extended description :

Potent CCR1 chemokine receptor antagonist

chemical name text :

1,4-cis-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide

formula :

C30H37Cl2IN2O2

formula text :

C30H37Cl2IN2O2

cas num :

202796-41-6

USD :

137 USD

product details :

Potent CCR1 chemokine receptor antagonist

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage