2592/10 | Tocris Bioscience 2592/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

2592/10

catalog :

2592/10

quantity :

10 mg (also 50 mg)

price :

292 USD

more info or order :

Tocris Bioscience product webpage

citations: 10

Reference
Kawai H, Bouchekioua Y, Nishitani N, Niitani K, Izumi S, Morishita H, et al. Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion. Nat Commun. 2022;13:7708 pubmed publisher
Nagata M, Yokooji T, Nakai T, Miura Y, Tomita T, Taogoshi T, et al. Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells. Sci Rep. 2019;9:16438 pubmed publisher
Afshar S, Shahidi S, Rohani A, Soleimani Asl S, Komaki A. Protective effects of 5-HT1A receptor antagonist and 5-HT2A receptor agonist on the biochemical and histological features in a rat model of Alzheimer's disease. J Chem Neuroanat. 2019;96:140-147 pubmed publisher
Alba Delgado C, Mountadem S, Mermet Joret N, Monconduit L, Dallel R, Artola A, et al. 5-HT2A Receptor-Induced Morphological Reorganization of PKCγ-Expressing Interneurons Gates Inflammatory Mechanical Allodynia in Rat. J Neurosci. 2018;38:10489-10504 pubmed publisher
Dong R, Yu B, Chen L, Yu W. The 5-HT2A receptor potassium-chloride cotransporter 2 signaling pathway in a rat incision pain model. Exp Ther Med. 2016;12:3583-3588 pubmed publisher
Hooper C, Delaney C, Streeter T, Yarboro M, Poole S, Brown N, et al. Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero. Am J Physiol Heart Circ Physiol. 2016;311:H572-81 pubmed publisher
Gerhold K, Drdla Schutting R, Honsek S, Forsthuber L, SandkÃ¼hler J. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci. 2015;35:9580-94 pubmed publisher
Watts S, Darios E, Seitz B, Thompson J. 5-HT is a potent relaxant in rat superior mesenteric veins. Pharmacol Res Perspect. 2015;3:e00103 pubmed publisher
Goda S, Piasecka J, Olszewski M, Kasicki S, Hunt M. Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens. Psychopharmacology (Berl). 2013;228:271-82 pubmed publisher
Niebert M, Vogelgesang S, Koch U, Bischoff A, Kron M, Bock N, et al. Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. PLoS ONE. 2011;6:e21395 pubmed publisher

product information

master code :

2592

SKU :

2592/10

product name :

TCB-2

unit size :

10 mg (also 50 mg)

description :

High affinity and potent 5-HT2A agonist

target :

5-HT2A Receptor Agonists

category :

Small Molecules

purity :

99%

observed molecular weight :

353.05

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TCB-2 is a high affinity 5-HT2A receptor agonist (Ki values are 0.73 and 0.75 nM for rat and human receptors respectively). Potently stimulates IP3 accumulation in NIH3T3 cells stably expressing rat 5-HT2A receptors (EC50 = 36 nM). Induces head twitches and hypothermia in mice following i.p. administration.

top caption :

High affinity and potent 5-HT2A agonist

extended description :

High affinity and potent 5-HT2A agonist

chemical name text :

(4-Bromo-3,6-dimethoxybenzocyclobuten-1-yl)methylamine hydrobromide

formula :

C11H14BrNO2.HBr

formula text :

C11H14BrNO2.HBr

cas num :

912342-28-0

USD :

292 USD

product details :

High affinity and potent 5-HT2A agonist

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage