PAC 1 | Tocris Bioscience 2581 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PAC 1

catalog :

2581

quantity :

10 mg (also 50 mg)

price :

159 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Chiu A, Wang J, Fiske M, Hubálková P, Barse L, Gray J, et al. NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content. Cell Rep. 2019;28:332-341.e5 pubmed publisher
Yosefzon Y, Soteriou D, Feldman A, Kostić L, Koren E, Brown S, et al. Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size. Mol Cell. 2018;70:573-587.e4 pubmed publisher

product information

brand :

Tocris

master code :

2581

SKU :

2581/10

product name :

PAC 1

description :

Activator of procaspase-3; pro-apoptotic

target :

Caspase Activators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

392.5

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC50 = 0.22 u M). Also activates procaspase-7 in a less efficient manner (EC50 = 4.5 u M). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC50 values are 0.003 - 1.41 and 5.02 - 9.98 u M respectively).

catalog number base :

2581

product keywords :

activators procaspase-3 proapoptotic Caspases Proteinases Proteases PAC1 Caspases Enzyme Substrates/ Activators 2581,

extended description :

Activator of procaspase-3; pro-apoptotic

chemical name text :

4-(Phenylmethyl)-1-piperazineacetic acid [[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide

formula :

C 23 H 28 N 4 O 2

formula text :

C23H28N4O2

cas num :

315183-21-2

2020 USD :

154

2021 USD :

159 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage