PB 28 dihydrochloride | Tocris Bioscience 2562/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PB 28 dihydrochloride

catalog :

2562/10

quantity :

10 mg (also 50 mg)

price :

204 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Cantonero C, Camello P, Abate C, Berardi F, Salido G, Rosado J, et al. NO1, a New Sigma 2 Receptor/TMEM97 Fluorescent Ligand, Downregulates SOCE and Promotes Apoptosis in the Triple Negative Breast Cancer Cell Lines. Cancers (Basel). 2020;12: pubmed publisher
Rennekamp A, Huang X, Wang Y, Patel S, Lorello P, Cade L, et al. ?1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol. 2016;12:552-8 pubmed publisher

product information

brand :

Tocris

master code :

2562

SKU :

2562/10

product name :

PB 28 dihydrochloride

unit size :

10 mg (also 50 mg)

seo description :

High affinity 2 agonist

target :

Sigma2 Receptor Agonists

category :

Small Molecules

purity :

99%

observed molecular weight :

443.5

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PB 28 dihydrochloride is a high affinity 2 receptor agonist (Ki values are 0.8 and 15.2 nM for 2 and 1 receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea pig bladder and ileum (EC50 values are 2.62 and 3.96 u M respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.

top caption :

High affinity 2 agonist

extended description :

High affinity 2 agonist

chemical name text :

1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine dihydrochloride

formula :

C24H38N2O.2HCl

formula text :

C24H38N2O.2HCl

cas num :

172907-03-8

USD :

204 USD

product details :

High affinity 2 agonist

storage :

Desiccate at +4░C

more info or order :

Tocris Bioscience product webpage