SB 218078 | Tocris Bioscience 2560 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SB 218078

catalog :

2560

quantity :

1 mg (also 10 mg)

price :

141 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Colin D, Hain K, Allan L, Clarke P. Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins. Open Biol. 2015;5:140156 pubmed publisher
Shirazi Fard S, All Ericsson C, Hallböök F. The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway. Cell Cycle. 2014;13:408-17 pubmed publisher
Ward S, Kim H, Komurov K, Mendiratta S, Tsai P, Schmolke M, et al. Host modulators of H1N1 cytopathogenicity. PLoS ONE. 2012;7:e39284 pubmed publisher
Luo Y, Lou S, Deng X, Liu Z, Li Y, Kleiboeker S, et al. Parvovirus B19 infection of human primary erythroid progenitor cells triggers ATR-Chk1 signaling, which promotes B19 virus replication. J Virol. 2011;85:8046-55 pubmed publisher
Persico A, Cervigni R, Barretta M, Corda D, Colanzi A. Golgi partitioning controls mitotic entry through Aurora-A kinase. Mol Biol Cell. 2010;21:3708-21 pubmed publisher
Azorsa D, Gonzales I, Basu G, Choudhary A, Arora S, Bisanz K, et al. Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. J Transl Med. 2009;7:43 pubmed publisher

product information

brand :

Tocris

master code :

2560

SKU :

2560/1

product name :

SB 218078

description :

Chk1 inhibitor

target :

Checkpoint Kinase Inhibitors

category :

Small Molecules

unit size :

1 mg (also 10 mg)

purity :

98%

observed molecular weight :

393.39

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively). Abrogates G2 cell cycle arrest caused by -irradiation and topoisomerase I inhibition. Potentiates cytotoxicity of DNA-damaging drugs, enhancing the efficacy of some chemotherapeutics.

catalog number base :

2560

product keywords :

inhibitors inhibits checkpoint kinase 1 Chk1 Chk2 Checkpoint Kinases Control SB218078 Checkpoint Kinases Checkpoint Control Kinases 2560,

extended description :

Chk1 inhibitor

chemical name text :

9,10,11,12-Tetrahydro- 9,12-epoxy-1H-diindolo[1,2,3-fg:3 ,2 ,1 -kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione

formula :

C 24 H 15 N 3 O 3

formula text :

C24H15N3O3

cas num :

135897-06-2

2020 USD :

135

2021 USD :

141 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage