SB 218078 | Tocris Bioscience 2560/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SB 218078

catalog :

2560/1

quantity :

1 mg (also 10 mg)

price :

178 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Lee Y, Muddaluru V, Anwar S, Wilson J, Campos A. A screen of kinase inhibitors reveals a potential role of Chk1 in regulating Hydra head regeneration and maintenance. Int J Dev Biol. 2021;65:523-536 pubmed publisher
Colin D, Hain K, Allan L, Clarke P. Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins. Open Biol. 2015;5:140156 pubmed publisher
Shirazi Fard S, All Ericsson C, Hallböök F. The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway. Cell Cycle. 2014;13:408-17 pubmed publisher
Pouliot L, Chen Y, Bai J, Guha R, Martin S, Gottesman M, et al. Cisplatin sensitivity mediated by WEE1 and CHK1 is mediated by miR-155 and the miR-15 family. Cancer Res. 2012;72:5945-55 pubmed publisher
Ward S, Kim H, Komurov K, Mendiratta S, Tsai P, Schmolke M, et al. Host modulators of H1N1 cytopathogenicity. PLoS ONE. 2012;7:e39284 pubmed publisher
Luo Y, Lou S, Deng X, Liu Z, Li Y, Kleiboeker S, et al. Parvovirus B19 infection of human primary erythroid progenitor cells triggers ATR-Chk1 signaling, which promotes B19 virus replication. J Virol. 2011;85:8046-55 pubmed publisher
Persico A, Cervigni R, Barretta M, Corda D, Colanzi A. Golgi partitioning controls mitotic entry through Aurora-A kinase. Mol Biol Cell. 2010;21:3708-21 pubmed publisher
Azorsa D, Gonzales I, Basu G, Choudhary A, Arora S, Bisanz K, et al. Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. J Transl Med. 2009;7:43 pubmed publisher

image

image 1 :

Cat.No. 2560 - SB 218078 C24H15N3O3 CAS No. 135897-06-2

product information

brand :

Tocris

master code :

2560

SKU :

2560/1

product name :

SB 218078

unit size :

1 mg (also 10 mg)

seo description :

Chk1 inhibitor

target :

Checkpoint Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

393.39

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively). Abrogates G2 cell cycle arrest caused by -irradiation and topoisomerase I inhibition. Potentiates cytotoxicity of DNA-damaging drugs, enhancing the efficacy of some chemotherapeutics.

top caption :

Chk1 inhibitor

extended description :

Chk1 inhibitor

chemical name text :

9,10,11,12-Tetrahydro- 9,12-epoxy-1H-diindolo[1,2,3-fg:3 ,2 ,1 -kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione

formula :

C24H15N3O3

formula text :

C24H15N3O3

cas num :

135897-06-2

USD :

178 USD

product details :

Chk1 inhibitor

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage