10-DEBC hydrochloride | Tocris Bioscience 2558/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

10-DEBC hydrochloride

catalog :

2558/10

quantity :

10 mg (also 50 mg)

price :

184 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Waltero C, de Abreu L, Alonso T, Nunes da Fonseca R, da Silva Vaz I, Logullo C. TOR as a Regulatory Target in Rhipicephalus microplus Embryogenesis. Front Physiol. 2019;10:965 pubmed publisher
Ali R, Samman N, Al Zahrani H, Nehdi A, Rahman S, Khan A, et al. Isolation and characterization of a new naturally immortalized human breast carcinoma cell line, KAIMRC1. BMC Cancer. 2017;17:803 pubmed publisher
Liddell J, Lehtonen S, Duncan C, Keksa Goldsteine V, Levonen A, Goldsteins G, et al. Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. J Neuroinflammation. 2016;13:49 pubmed publisher
Sokołowska P, Urbańska A, Biegańska K, Wagner W, Ciszewski W, Namiecinska M, et al. Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling. J Mol Neurosci. 2014;52:48-55 pubmed publisher
Goodnough J, Ramos E, Nemeth E, Ganz T. Inhibition of hepcidin transcription by growth factors. Hepatology. 2012;56:291-9 pubmed publisher
Gangoiti P, Bernacchioni C, Donati C, Cencetti F, Ouro A, Gomez Munoz A, et al. Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts. Biochimie. 2012;94:597-607 pubmed publisher

product information

brand :

Tocris

master code :

2558

SKU :

2558/10

product name :

10-DEBC hydrochloride

unit size :

10 mg (also 50 mg)

seo description :

Selective Akt/PKB inhibitor

target :

Akt (Protein Kinase B) Inhibitors

category :

Small Molecules

purity :

99%

observed molecular weight :

381.34

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

10-DEBC hydrochloride is a selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 u M), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC50 ~ 2-6 u M) and induces apoptosis in rhabdomyosarcoma cells.

top caption :

Selective Akt/PKB inhibitor

extended description :

Selective Akt/PKB inhibitor

chemical name text :

10-[4 -(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride

formula :

C20H25N2OCl.HCl

formula text :

C20H25N2OCl.HCl

cas num :

925681-41-0

USD :

184 USD

product details :

Selective Akt/PKB inhibitor

alt names :

Akt Inhibitor X

storage :

Desiccate at +4░C

more info or order :

Tocris Bioscience product webpage