GYKI 53655 hydrochloride | Tocris Bioscience 2555 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GYKI 53655 hydrochloride

catalog :

2555

quantity :

10 mg (also 50 mg)

price :

231 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Lu H, Balmer T, Romero G, Trussell L. Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters. Neuron. 2017;96:73-80.e4 pubmed publisher
Droste D, Seifert G, Seddar L, Jädtke O, Steinhäuser C, Lohr C. Ca2+-permeable AMPA receptors in mouse olfactory bulb astrocytes. Sci Rep. 2017;7:44817 pubmed publisher
Murphy Baum B, Taylor W. The Synaptic and Morphological Basis of Orientation Selectivity in a Polyaxonal Amacrine Cell of the Rabbit Retina. J Neurosci. 2015;35:13336-50 pubmed publisher
Astorga G, Bao J, Marty A, Augustine G, Franconville R, Jalil A, et al. An excitatory GABA loop operating in vivo. Front Cell Neurosci. 2015;9:275 pubmed publisher
Ben Simon Y, Rodenas Ruano A, AlviÃ±a K, Lam A, Stuenkel E, Castillo P, et al. A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity. Cell Rep. 2015;12:396-404 pubmed publisher
Falgairolle M, O Donovan M. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. PLoS ONE. 2015;10:e0131430 pubmed publisher
Höft S, Griemsmann S, Seifert G, Steinhäuser C. Heterogeneity in expression of functional ionotropic glutamate and GABA receptors in astrocytes across brain regions: insights from the thalamus. Philos Trans R Soc Lond B Biol Sci. 2014;369:20130602 pubmed publisher
Buldyrev I, Puthussery T, Taylor W. Synaptic pathways that shape the excitatory drive in an OFF retinal ganglion cell. J Neurophysiol. 2012;107:1795-807 pubmed publisher
Tang M, Pelkey K, Ng D, Ivakine E, McBain C, Salter M, et al. Neto1 is an auxiliary subunit of native synaptic kainate receptors. J Neurosci. 2011;31:10009-18 pubmed publisher
Straub C, Hunt D, Yamasaki M, Kim K, Watanabe M, Castillo P, et al. Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1. Nat Neurosci. 2011;14:866-73 pubmed publisher
De Biase L, Nishiyama A, Bergles D. Excitability and synaptic communication within the oligodendrocyte lineage. J Neurosci. 2010;30:3600-11 pubmed publisher

product information

brand :

Tocris

master code :

2555

SKU :

2555/10

product name :

GYKI 53655 hydrochloride

description :

Non-competitive non-NMDA iGluR antagonist

target :

AMPA Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

388.85

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Non-competitive AMPA and kainate receptor antagonist. Analog of GYKI 52466 (Cat. No. 1454). Prolongs the survival time after MgCl2- induced global cerebral ischemia. Exhibits anticonvulsant activity. Also blocks GluK3 homomeric receptors (IC50 = 63 M) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 M) at high concentrations.

catalog number base :

2555

product keywords :

GYKI53655 hydrochloride non-competitive AMPA receptors kainate antagonists GluK3 AMPA Receptors Kainate Receptors 2555,

extended description :

Non-competitive non-NMDA iGluR antagonist

chemical name text :

1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride

formula :

C 19 H 20 N 4 O 3 .HCl

formula text :

C19H20N4O3.HCl

cas num :

143692-48-2

2020 USD :

220

2021 USD :

231 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage