ZIP | Tocris Bioscience 2549/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ZIP

catalog :

2549/1

quantity :

1 mg

price :

292 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Awasthi A, Ramachandran B, Ahmed S, Benito E, Shinoda Y, Nitzan N, et al. Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting. Science. 2019;363: pubmed publisher
Mirza A, Fry M, Urman N, Atwood S, Roffey J, Ott G, et al. Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment. JCI Insight. 2017;2: pubmed publisher
Grosso A, Cambiaghi M, Renna A, Milano L, Roberto Merlo G, Sacco T, et al. The higher order auditory cortex is involved in the assignment of affective value to sensory stimuli. Nat Commun. 2015;6:8886 pubmed publisher
Han J, Kwon M, Cha M, Tanioka M, Hong S, Bai S, et al. Plasticity-Related PKMÎ¶ Signaling in the Insular Cortex Is Involved in the Modulation of Neuropathic Pain after Nerve Injury. Neural Plast. 2015;2015:601767 pubmed publisher
Balaban P, Roshchin M, Timoshenko A, Zuzina A, Lemak M, Ierusalimsky V, et al. Homolog of protein kinase MÎ¶ maintains context aversive memory and underlying long-term facilitation in terrestrial snail Helix. Front Cell Neurosci. 2015;9:222 pubmed publisher
Chen A, Bao C, Tang Y, Luo X, Guo L, Liu B, et al. Involvement of protein kinase Î¶ in the maintenance of hippocampal long-term potentiation in rats with chronic visceral hypersensitivity. J Neurophysiol. 2015;113:3047-55 pubmed publisher
Lee A, Kanter B, Wang D, Lim J, Zou M, Qiu C, et al. Prkcz null mice show normal learning and memory. Nature. 2013;493:416-9 pubmed publisher
Laferriere A, Pitcher M, Haldane A, Huang Y, Cornea V, Kumar N, et al. PKM? is essential for spinal plasticity underlying the maintenance of persistent pain. Mol Pain. 2011;7:99 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2549

SKU :

2549/1

product name :

ZIP

description :

Cell-permeable inhibitor of atypical PKC isozyme PKM

target :

Protein Kinase C Inhibitors

unit size :

1 mg

category :

Peptides

purity :

95%

storage :

Store at -20°C

observed molecular weight :

1928.4

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

ZIP is a novel, cell-permeable inhibitor of protein kinase M (PKM ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKM -induced synaptic potentiation in hippocampal slices in vitro . Reverses late-phase LTP (IC50 = 1 - 2.5 u M) and produces persistent loss of 1-day-old spatial memory following central administration in vivo . . Control Peptide and Biotinylated Peptide also available.

product keywords :

Cell-permeable inhibitors inhibits atypical PKC isozyme PKMzeta Protein Kinases C z-Pseudosubstrate inhibitory peptide Protein Kinase C 2549,

extended description :

Cell-permeable inhibitor of atypical PKC isozyme PKM

formula :

C90H154N30O17

formula text :

C90H154N30O17

cas num :

863987-12-6

USD :

289

USD 2025 :

292 USD

product details :

Cell-permeable inhibitor of atypical PKC isozyme PKM

alt names :

z-Pseudosubstrate inhibitory peptide

more info or order :

Tocris Bioscience product webpage